Search Results - technology+classifications+%3e+drug+design+and%2for+synthesis

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LpxC Inhibitors for Gram-Negative Infections

Treatment of multidrug-resistant bacterial infections with LpxC inhibitors for reduced drug resistance and improved safety profiles RSS.HDBackground> Background: < Infection by Gram‑negative bacteria such as Pseudomonas aeruginosa, β‑lactamase producing (ESBL) Enterobacteriaceae, and Acinetobacter baumannii is a major health problem, especially...

Published: 3/7/2025 | Inventor(s): Peter Tonge, Fereidoon Daryaee, Sneha Basak

Keywords(s):

Category(s): Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Therapeutics, Campus > Stony Brook University

Design and Synthesis of Novel Methotrexate Conjugated MicroRNA Mimic Modified with 5-Fluorouracil and/or Gemcitabine as a Platform Technology for Cancer Treatment

A platform for modifying miRNAs and using the modified miRNAs as novel cancer therapeutics. RSS.HDBackground> Background: < Resistance to chemotherapy can be a highly complex issue, with epigenetic alterations playing a key role in tumorigenesis and chemotherapy resistance. The failure to treat several advanced solid tumors can be often attributed...

Published: 3/7/2025 | Inventor(s): Jingfang Ju, Iwao Ojima, John Yuen, Lei Chen

Keywords(s):

Category(s): Technology Classifications > Therapeutics, Technology Classifications > Drug Design and/or Synthesis, Campus > Stony Brook University

Concerted, Selective Radiometallation and Photo-triggered Release of Ready-to-Inject Radiopharmaceuticals from the Solid Phase

Solid Phase Radiometallation Photorelease method for the preparation of injectable radiopharmaceuticals RSS.HDBackground> Background: < Radiopharmaceuticals are agents which enable non-invasive patient diagnosis and personalized therapeutic intervention strategies. Radionuclides used in nuclear medicine applications must be purified after nuclear...

Published: 2/4/2025 | Inventor(s): Eszter Boros, Dariusz Śmiłowicz

Keywords(s):

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Drug Design and/or Synthesis, Campus > Stony Brook University

6-azasteroids with unique activity in mycobacteria

The compound functions as potentiators of several anti-tuberculosis drugs RSS.HDBackground> Background: < One third of the world’s population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. There are drugs to combat the bacteria by attacking the bacteria directly. The current recommended treatment...

Published: 2/4/2025 | Inventor(s): Nicole Sampson, Joshua Werman, Tianao Yuan

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Category(s): Technology Classifications, Technology Classifications > Drug Design and/or Synthesis, Campus > Stony Brook University

Metal-mediated, Autolytic Amide Bond Cleavage for the Selective, Metal-Complexation Catalyzed, Controlled Release of Metallodrugs

Autolytic, metal complex-mediated amide bond cleavage for prodrug activation and synthesis of metallodrugs RSS.HDBackground> Background: < Clinically viable prodrugs release activated drug molecules at the site of interest, requiring close spatiotemporal control. Bond cleavage strategies for the release of the activated drug often incorporate...

Published: 2/4/2025 | Inventor(s): Eszter Boros, Dariusz Śmiłowicz

Keywords(s):

Category(s): Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Drug Delivery, Campus, Campus > Stony Brook University

Immunostimulant-Cytotoxic Conjugates for Targeted Cancer Therapy

050-9150 Immunostimulant-Cytotoxic Conjugates for Targeted Cancer Therapy A unique immunotherapy paradigm to treat castrate-resistant prostate cancer and its metastatic form RSS.HDBackground> Background: < Prostate cancer is one of the leading causes of cancer death, with 1 in 10 men diagnosed in their lifetime and 1 in 41 dying from the...

Published: 9/25/2024 | Inventor(s): Labros Meimetis, Eszter Boros

Keywords(s): Technologies

Category(s): Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics, Campus > Stony Brook University

Enzymatic Capsulotomy for Shoulder Adhesive Capsulitis

A minimally invasive collagenase injection method for treating frozen shoulder that is cost-effective Background: Adhesive capsulitis of the shoulder, more commonly known as frozen shoulder, results in painful limitation of shoulder motion. It can arise idiopathically or after trauma. The current standard of care is a long course of painful physical...

Published: 11/25/2024 | Inventor(s): Marie Badalamente, Edward Wang

Keywords(s): Collagenase Injection, Frozen shoulder, Nonoperative Therapy, Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Therapeutics

Alkene Isomerization as an Entry to Efficient Alternating Ring-opening Metathesis Polymerization (iAROMP)

A technique that enables the preparation of long length and low dispersion polymers with an alternating functional group arrangement Background: Most sequence-controlled polymers lack rigorous fidelity or are homopolymers with simple chain microstructures or copolymers, in which the monomer sequence is not precisely controlled. Polymers of imprecise...

Published: 8/28/2024 | Inventor(s): Nicole Sampson, Li Tan, Kathlyn Parker

Keywords(s): alkene isomerization, Grubbs catalyst, ROMP, ruthenium, Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Research Tools and Reagents

Novel Bioabsorbable Membranes for Cell Delivery Applications

Methods for storing viable cells and for delivering viable cells to a mammal using the cell storage and delivery system. Background: Methods and compositions for encapsulating core materials, e.g., materials containing drugs, have been disclosed. These methods generally involve encapsulating the core material within a micro capsule by forming...

Published: 11/25/2024 | Inventor(s): Benjamin Chu, Benjamin Hsiao, Michael Hadjiargyrou, Dufei Fang, Xinhua Zong, KwangSok Kim

Keywords(s):

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Delivery, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Gene Therapy and Viral Vectors

Novel Drugs for the Treatment of Tuberculosis

Compounds that increase TB therapy efficacy through a mechanism of action for increased tolerance and decreased therapy duration. Background: One third of the world's population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. The current recommended treatment regimen for TB begins with a two-month intensive therapy...

Published: 8/27/2024 | Inventor(s): Nicole Sampson, Xinxin Yang, Tianao Yuan

Keywords(s):

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis

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