Search Results - nicole+sampson

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6-azasteroids with unique activity in mycobacteria

The compound functions as potentiators of several anti-tuberculosis drugs RSS.HDBackground> Background: < One third of the world’s population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. There are drugs to combat the bacteria by attacking the bacteria directly. The current recommended treatment...

Published: 2/4/2025 | Inventor(s): Nicole Sampson, Joshua Werman, Tianao Yuan

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Category(s): Technology Classifications, Technology Classifications > Drug Design and/or Synthesis, Campus > Stony Brook University

Alkene Isomerization as an Entry to Efficient Alternating Ring-opening Metathesis Polymerization (iAROMP)

A technique that enables the preparation of long length and low dispersion polymers with an alternating functional group arrangement Background: Most sequence-controlled polymers lack rigorous fidelity or are homopolymers with simple chain microstructures or copolymers, in which the monomer sequence is not precisely controlled. Polymers of imprecise...

Published: 8/28/2024 | Inventor(s): Nicole Sampson, Li Tan, Kathlyn Parker

Keywords(s): alkene isomerization, Grubbs catalyst, ROMP, ruthenium, Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Research Tools and Reagents

Degradable Polymeric Materials via Large Ring Alternating Ring Opening Metathesis Polymerization (AROMP)

An effective way of designing a myriad of intelligent materials that are readily degradable and easily synthesized Background: Ring opening metathesis polymerization is a technique which enables the synthesis of materials of diverse architecture owing to its tolerance to a large range of functionalities. Traditionally, the scope of monomers used yields...

Published: 5/8/2024 | Inventor(s): Nicole Sampson, Jingling Zhang, Francis Boadi, Guofang Li

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Category(s): Campus > Stony Brook University, Technology Classifications > Drug Delivery, Technology Classifications > Electronics and Electronic Materials, Technology Classifications > Material and Composites, Technology Classifications > Therapeutics

Novel Drugs for the Treatment of Tuberculosis

Compounds that increase TB therapy efficacy through a mechanism of action for increased tolerance and decreased therapy duration. Background: One third of the world's population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. The current recommended treatment regimen for TB begins with a two-month intensive therapy...

Published: 8/27/2024 | Inventor(s): Nicole Sampson, Xinxin Yang, Tianao Yuan

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Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis

Novel Inhibitors of Matrix Metalloproteinase-9 for Anti-Cancer Drug Development

Inhibitors that target a site on MMP-9's hemopexin domain that are distinct and cannot be functionally substituted for one another. Background: Matrix Metalloproteinase-9 (MMP-9), a type IV collagenase, is linked to cancer progression and metastasis. Despite increased evidence of correlation between MMP-9 and tumor metastasis, no success has been...

Published: 9/27/2024 | Inventor(s): Vincent Alford, Anushree Kamath, Jian Cao, Nicole Sampson, Iwao Ojima, Xiaodong Ren, Monaf Awwa

Keywords(s): Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Research Tools and Reagents