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Development of a Pediatric Tuberculosis Diagnostic Test
A lipoprotein diagnostic marker for TB disease ideal for a simple diagnostic assay from a finger prick blood or serum Background: The inadequate sensitivity of available organism-based TB diagnostic tools in children, the wide spectrum of disease observed in children, and the non-specific signs and symptoms especially in young and HIV-children,...
Published: 2/28/2024
|
Inventor(s):
Nicole Sampson
,
Xinxin Yang
Keywords(s):
antibody
,
biomarker
,
diagnosis
,
ELISA
,
modified LDL
,
Technologies
,
tuberculosis
Category(s):
Campus > Stony Brook University
,
Technology Classifications > Antibodies
,
Technology Classifications > Diagnostics
Alkene Isomerization as an Entry to Efficient Alternating Ring-opening Metathesis Polymerization (iAROMP)
A technique that enables the preparation of long length and low dispersion polymers with an alternating functional group arrangement Background: Most sequence-controlled polymers lack rigorous fidelity or are homopolymers with simple chain microstructures or copolymers, in which the monomer sequence is not precisely controlled. Polymers of imprecise...
Published: 11/22/2023
|
Inventor(s):
Nicole Sampson
,
Li Tan
,
Kathlyn Parker
Keywords(s):
alkene isomerization
,
Grubbs catalyst
,
ROMP
,
ruthenium
,
Technologies
Category(s):
Campus > Stony Brook University
,
Technology Classifications > Drug Design and/or Synthesis
,
Technology Classifications > Research Tools and Reagents
Degradable Polymeric Materials via Large Ring Alternating Ring Opening Metathesis Polymerization (AROMP)
An effective way of designing a myriad of intelligent materials that are readily degradable and easily synthesized Background: Ring opening metathesis polymerization is a technique which enables the synthesis of materials of diverse architecture owing to its tolerance to a large range of functionalities. Traditionally, the scope of monomers used yields...
Published: 11/22/2023
|
Inventor(s):
Nicole Sampson
,
Jingling Zhang
,
Francis Boadi
,
Guofang Li
Keywords(s):
Category(s):
Campus > Stony Brook University
,
Technology Classifications > Drug Delivery
,
Technology Classifications > Electronics and Electronic Materials
,
Technology Classifications > Material and Composites
,
Technology Classifications > Therapeutics
Novel Drugs for the Treatment of Tuberculosis
Compounds that increase TB therapy efficacy through a mechanism of action for increased tolerance and decreased therapy duration. Background: One third of the world's population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. The current recommended treatment regimen for TB begins with a two-month intensive therapy...
Published: 6/5/2023
|
Inventor(s):
Nicole Sampson
,
Xinxin Yang
,
Tianao Yuan
Keywords(s):
Category(s):
Campus > Stony Brook University
,
Technology Classifications > Drug Design and/or Synthesis
Novel Inhibitors of Matrix Metalloproteinase-9 for Anti-Cancer Drug Development
Inhibitors that target a site on MMP-9's hemopexin domain that are distinct and cannot be functionally substituted for one another. Background: Matrix Metalloproteinase-9 (MMP-9), a type IV collagenase, is linked to cancer progression and metastasis. Despite increased evidence of correlation between MMP-9 and tumor metastasis, no success has been...
Published: 2/28/2024
|
Inventor(s):
Vincent Alford
,
Anushree Kamath
,
Jian Cao
,
Nicole Sampson
,
Iwao Ojima
,
Xiaodong Ren
Keywords(s):
Technologies
Category(s):
Campus > Stony Brook University
,
Technology Classifications > Drug Design and/or Synthesis
,
Technology Classifications > Research Tools and Reagents