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Design and Synthesis of Novel Methotrexate Conjugated MicroRNA Mimic Modified with 5-Fluorouracil and/or Gemcitabine as a Platform Technology for Cancer Treatment
A platform for modifying miRNAs and using the modified miRNAs as novel cancer therapeutics. RSS.HDBackground> Background: < Resistance to chemotherapy can be a highly complex issue, with epigenetic alterations playing a key role in tumorigenesis and chemotherapy resistance. The failure to treat several advanced solid tumors can be often attributed...
Published: 3/7/2025
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Inventor(s):
Jingfang Ju
,
Iwao Ojima
,
John Yuen
,
Lei Chen
Keywords(s):
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Drug Design and/or Synthesis
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Campus > Stony Brook University
Device for Rapid Simple and Highly Parallel Single-Cell Processing Including Spatial Analaysis
An innovative device based on a modified array of microwells representing the next-generation of single-cell and spatial genomics platforms Background: Technologies for preparing samples for single-cell genomic applications have revolutionized the way scientists interrogate tissues by enabling the detailed deciphering of their composition. Recently,...
Published: 9/6/2024
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Inventor(s):
Eric Brouzes
,
Jin Zhu Yu
,
Anu Priya Bharathirajan
,
Jingfang Ju
,
Gabor Balazsi
Keywords(s):
Technologies
Category(s):
Campus > Stony Brook University
,
Technology Classifications > Medical Devices
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Technology Classifications > Research Tools and Reagents