Electronic Health Records Management via Blockchain

linda.galvin@stonybrook.edu — Thu, 17 Nov 2022 13:20:36 GMT

Using blockchain technology to make the data transfer and management of electronic health records more secure, efficient, and fastRSS.HDBackground> Background:

Oxide polygonal prism nanocages for trapping of gases

linda.galvin@stonybrook.edu — Thu, 17 Nov 2022 13:16:52 GMT

An activated physisorption mechanism that uses 2D (alumino)silicate films in the form of hexagonal prism nanocages to trap noble gasesRSS.HDBackground> Background:

Metal-oxide infiltrated organic-inorganic hybrid resistive random-access memory (ReRAM) devices

linda.galvin@stonybrook.edu — Thu, 17 Nov 2022 13:16:29 GMT

A resistive switching medium of organic-inorganic hybrid composite films for ReRAM devicesRSS.HDBackground> Background:

Ultra-high-k SrTiO3 hole blocking layer for low excess noise solid-state amorphous selenium avalanche detector

linda.galvin@stonybrook.edu — Thu, 17 Nov 2022 13:16:19 GMT

A low-noise selenium based solid-state avalanche detector that will use strontium titanate as the high-k dielectric hole-blocking n-layerRSS.HDBackground> Background:

High Temperature Metal Hydride Composite Moderators for Shielding Applications

linda.galvin@stonybrook.edu — Thu, 10 Nov 2022 13:30:51 GMT

A composite moderator formed by entraining metal hydrides within an irradiation-stable and moderating ceramic matrix of Magnesium OxideRSS.HDBackground> Background:

Immunostimulant-Cytotoxic Conjugates for Targeted Cancer Therapy

linda.galvin@stonybrook.edu — Tue, 09 Aug 2022 13:43:47 GMT

050-9150 Immunostimulant-Cytotoxic Conjugates for Targeted Cancer Therapy A unique immunotherapy paradigm to treat castrate-resistant prostate cancer and its metastatic form RSS.HDBackground> Background: < Prostate cancer is one of the leading causes of cancer death, with 1 in 10 men diagnosed in their lifetime and 1 in 41 dying from the disease. Globally, there are 1.3 million new cases of prostate cancer every year and 360,000 associated deaths. Up to 50% of patients will eventually become refractory to androgen deprivation therapy and progress to castrate-resistant prostate ...

Bioresorbable Zinc-Based Surgical Staples

linda.galvin@stonybrook.edu — Wed, 09 Mar 2022 13:42:58 GMT

050- 9154 InPart Bioresorbable Zinc-Based Surgical Staples Biodegradable and implantable implants made of metallic zinc alloys and/or composite to close a surgical wound RSS.HDBackground> Background: < Over 28 million surgeries are performed each year in America, and about 10 million operations of those are on the digestive system. To end off gastrointestinal surgeries, stapled anastomosis (SA) or hand‑sewn anastomosis (HA) are used. Ever since SA has been introduced, it has been found that SA is associated with reduced tissue manipulation, better blood supply, less edema...

Triazamacrocycle-derived Chelators for the Coordination of Imaging and Therapy Metal Ions

linda.galvin@stonybrook.edu — Fri, 04 Dec 2020 08:46:26 GMT

Rapid and inert radiolabeling with an array of radioactive isotopes suitable for medical imaging and therapy approaches. Background: Personalized medicine, or individually tailored patient treatment, is an emerging clinical management paradigm. In nuclear medicine, this entails exploiting diagnostic techniques, such as non-invasive imaging by means of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT), to modify radiotherapeutic treatment regimes. If the same drug is labeled with a diagnostic and a therapeutic radionuclide for sequential imagin...

Novel Process for Measuring Nitrate/Nitrite and Ammonium in Wastewater Simultaneously

linda.galvin@stonybrook.edu — Mon, 12 Oct 2020 07:51:10 GMT

Using a strong alkaline solution and a gas-permeable membrane to measure the concentration of ammonium/ammonia/nitrite/nitrate in wastewater Background: Due to the growing problems with the conventional processes for treating wastewater, there has recently been a spur in the development and design of a low‑cost nitrogen sensor package that can measure and monitor nitrate and ammonium in septic systems. Conventional processes for wastewater treatments are either too expensive, too ineffective, or simply too time-consuming. Therefore, there is a need for a method and apparatus that i...

Large-Scale Sentiment Analysis for News and Blogs

linda.galvin@stonybrook.edu — Thu, 03 Sep 2020 12:17:19 GMT

A method for determining a sentiment associated with an entity Background: Sentiment analysis of natural language texts is a large and growing field. Some methods for generating sentiment lexicons assume positive and negative sentiment using synonyms and antonyms. Such methods may not accurately capture the sentiment of a word. Other methods use semantics, such as "and" and "but", or tone/orientation to determine a sentiment of a word, but such methods may have low accuracy. Current methods for analyzing sentiment treat only single complete documents, for example, ...

Method and Apparatus for High Efficiency X-ray Imager

linda.galvin@stonybrook.edu — Fri, 28 Aug 2020 12:36:31 GMT

An x-ray detector with improved dynamic range and sensitivity that improves the quantum efficiency of x-ray imagers Background: X-ray imaging experienced a ?digital revolution? in the early 2000s, with digital radiography systems being implemented with active matric flat panel images. Due to the compact size, rapid image readout and excellent image quality, AMFPI is being used not only for traditional x-ray imaging modalities such as general radiography and fluoroscopy, but also in tomographic imaging applications. Technology Overview: The detectors proposed here provide an improved d...

Process for Predicting Community Real Estate Outcomes Using Social Media

linda.galvin@stonybrook.edu — Fri, 28 Aug 2020 12:13:16 GMT

Tracking information about communities that is not available otherwise to better predict prices Background: Technology Overview: This technology tracks information about communities that is not available otherwise. It has shown it can predict prices better than those variables alone. Advantages: Inpart-Benefits Applications: Intellectual Property Summary: Stage of Development: Working prototype available for demonstration. Licensing Potential: Development partner - Commercial partner - Licensing Licensing Status: Available for license. Stony Brook University se...

A Piezoelectric-triboelectric Heel Charger for Power-on-the-go

linda.galvin@stonybrook.edu — Fri, 28 Aug 2020 11:28:10 GMT

A heel charger that uses a level mechanism and a mechanical SSHI boosting circuit to provide electrical energy Background: Running out of battery power often results in life-threatening situations, whereas backup batteries are large, heavy and hazardous. In efforts to treat this unreliable aspect, proposed is an energy harvester. This is a clean alternative solution to such problems, with the ability to power electronics on the go. Technology Overview: This invention entails a high power density heel charger, providing a USB port or datable rechargeable battery. The high-power density...

Hybrid Active Matrix Flat Panel Imager

linda.galvin@stonybrook.edu — Fri, 28 Aug 2020 10:51:46 GMT

A hybrid x-ray detector that absorbs incident rays directly and indirectly, and the photoconductor can sense both x-rays and optical photons Background: X-ray detectors currently commercially available consist of direct and indirect detectors. Direct detectors take x-ray inputs and are directly converted to electron hole pairs and digitized through the readout electronics. Common photoconductors are amorphous selenium. Indirect detectors use a phosphor screen to later convert x-rays to optical photons, absorbed in a photodiode and digitized. Higher energy applications and cu...

Cavity-Enhanced Two-Dimensional Spectrometer

linda.galvin@stonybrook.edu — Fri, 28 Aug 2020 09:41:17 GMT

A method to perform passively amplified 2D spectroscopy experiments with a frequency comb and optical cavities approach implemented. Background: Fundamental studies in physics and chemistry include spectroscopy of gas-phase atoms and molecules, developing essential components of quantum mechanics. Technology Overview: This invention is a method to perform passively amplified 2D spectroscopy experiments, and a frequency comb and optical cavities approach was implemented. Implementation is created through coupling multiple frequency combs to higher-order cavity modes, background-fre...

Similarity Preserving Color Mapping Scheme for Multivariate Data

linda.galvin@stonybrook.edu — Fri, 28 Aug 2020 08:43:43 GMT

A framework that uses the HSL color space for mapping data to color and is ideal for environmental assessments and scientific simulations Background: Mapping data to color has a rich history and several well-tested color schemes have emerged. Most of these, however are defined for scalar data where the scalar value indexes a one-dimensional table that returns an RGB color triple. Schemes assign color to different, usually disjoint materials and then use standard blending functions to handle areas where materials overlap or mix together. This process forces graphical rendering of simulatio...

Data Memes: Automatically Merging Data with Supporting Visuals

linda.galvin@stonybrook.edu — Fri, 28 Aug 2020 07:48:40 GMT

A framework for displaying user data as data memes, an artistic visualization of data for increasing engagement Background: The information age is upon us and in recent years millions of terabytes of data are generated every day. This growing chunk of data is related to personal lives- information about ourselves and communities and issues that have personal relevance. In efforts to make sense of it, they have turned information into visuals. These visuals are designed to represent opinions and alongside using charts. Technology Overview: This framework uses what is known about the dat...

System, Method, and Accelerator to Process Convolutional Neural Network Layers

linda.galvin@stonybrook.edu — Fri, 28 Aug 2020 07:38:40 GMT

A CNN hardware accelerator that improves energy efficiency ideal for architectures that focus on the dataflow across convolutional layers Background: Deep convolutional neural networks (CNNs) are rapidly becoming the dominant approach to computer vision and a major component of many other pervasive machine learning tasks. Technology Overview: Developed is a novel CNN hardware accelerator with a new architecture and design methodology. Modified is the order in which the original input data are brought on to the chip. The design approach is a pyramid-shaped multi-layer sliding window, a...

Condensing Flue Gas for Sub-Ambient Evaporative Cooling and Cool Storage

linda.galvin@stonybrook.edu — Fri, 28 Aug 2020 06:57:41 GMT

An evaporator and condenser arrangement that allows indefinite heat storage times for power plants without additional refrigeration systems Background: A thermosyphon uses the latent heat of vaporization rather than a temperature gradient for heat transfer. Power plants don?t require a large body of water for cooling and consume little to no water for operation, significantly enhancing US electricity potential. Thermal resistance for heat transfer can be reduced, the condensate will be stored and used for subsequent evaporative cooling using commercially available technologies. Technolo...

Electrochemical Synthesis of Chloro-Chitosan

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 13:56:29 GMT

A chitosan polymer that retains its natural biocompatibility making it ideal for environmental applications such as water filtration Background: Chitosan has extensively used polysaccharide derived from deacetilization of chitin, which is the second most abundant biopolymer. Presence of primary amine, primary hydroxyl as well as secondary hydroxyl groups make chitosan very amenable to further fictionalization and modification; consequently, chitosan has been modified in numerous ways which can be broadly classified in physical, chemical and enzymatic modification categories. Owing to exte...

Digital Image Speckle Correlation (DISC) Analysis for Subcutaneous Muscle Motion and Nerve Function

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 13:39:22 GMT

A technique that uses photographic analysis to calculate the magnitude and vector of muscle contraction to determine nerve function Background: Digital Image Speckle Correlation (DISC) has previously been used in animal studies of skin dynamics. In addition, the technology has been applied toward characterizing the biomechanical properties of human skin and the effects of ageing, as well as the analysis of mechanical properties of metals. The proposed innovation will extend DISC to direct clinical applications. Technology Overview: Researchers at Stony Brook University have invented ...

Crosslinked Thermoreversible Pluronic Hydrogels for Prosthetic Disc Nucleus Replacement

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 13:25:06 GMT

An easily injectable crosslinked hyaluronic acid-gelatin hydrogel that can be used as a prosthetic replacement for a spinal disc nucleus Background: When a spinal disc becomes damaged due to trauma or disease resulting in a disc herniation, it may become necessary to replace a natural spinal disc nucleus with a prosthesis. Such prostheses should preferably mimic the shape and function of the natural nucleus. Several varieties of prostheses have been proposed for replacing the natural disc nucleus, however these prostheses may exert additional pressure on the annulus and can further...

Enhancing Responses to Chemical Interventions by Programmed Introduction of Multiple Refractory Periods

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 13:10:50 GMT

A medical device that can deliver multiple, brief intervention doses over a 24 hour period that improves cell biologic responses. Background: The ability of any exogenous intervention, be it physical or chemical in nature, to influence cell activity is markedly enhanced by incorporating a rest period between stimulation periods within any given 24 hour period. Thus, a 24 hour period does not need to transpire before the biologic responsiveness to a given stimulus is ?reset.? Technology Overview: Researchers at Stony Brook University created an invention which indicates that the poten...

Novel EGFR Truncations as Biomarker and Target

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 12:46:25 GMT

Three mutations that could be used as biomarkers for patient's drug responses or for tumor therapeutic targets Background: Three new truncation mutants have been discovered in primary human tumors and cell lines. These mutants may possess oncogenic activities and render some tumors resistant to certain inhibitors. These newly discovered mutants may be used as biomarkers for predicting patients? response to specific targeting agents. Technology Overview: Researchers at Stony Brook University discovered three new truncation mutants of EGFR in primary human tumors and cell lines. These m...

Methods of Treating and Preventing Angioedema and Vascular Leakage

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 12:27:14 GMT

Peptides and antibodies that block vascular permeability induced in angioedema patients that are new targets for treatment. Background: Angioedema associated with C1-INH deficiency is an inherited or acquired condition that affects 20 per cent of the population. The condition can be disfiguring, painful and sometimes fatal. Existing treatments primarily replace or enhance the production of C1-INH, but these options are limited to availability, price, side effects, and long term risks. New therapeutic modalities that address these issues are sorely needed. Technology Overview: Research...

Monoclonal Antibody, Anti Ft LVS LpnA/Tu14 Clone 164

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 12:11:17 GMT

An intracellular bacterium that can initiate the human response to Tularemia Background: Francisella tularensis is an intracellular, gram-negative bacterium that invades macrophages and initiates the human immune response. Technology Overview: Tularemia, commonly known as ?rabbit fever? can be communicated across several species including; rabbits, rodents and humans. The murine monoclonal antibody recognizes a native epitope of Francisella tularensis ?Live Vaccine Strain?; IgG monoclonal antibody clone 164 against a native epitope of Francisella tularensis...

Extraction of Respiratory Rate from Pulse Oximeter Recordings

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 12:02:00 GMT

An algorithm that uses pulse oximeter signals to estimate a respiratory rate with more accurate results and time-frequency resolution Background: Pulse oximeters are simple, non-invasive instruments used extensively in hospitals and emergency rooms to acquire patient oxygen saturation and cardiac functions. To maximize the potential of pulse oximetry, researchers have explored additional measurements, including respiratory rates. Today, respiratory rates can only be determined with costly equipment and additional sensors that patients often find uncomfortable, which further ...

Enzymatic Capsulotomy for Shoulder Adhesive Capsulitis

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 11:21:45 GMT

A minimally invasive collagenase injection method for treating frozen shoulder that is cost-effective Background: Adhesive capsulitis of the shoulder, more commonly known as frozen shoulder, results in painful limitation of shoulder motion. It can arise idiopathically or after trauma. The current standard of care is a long course of painful physical therapy to restore shoulder motion. Failing that, patients? often undergo surgical procedures, such as manipulation under general anesthesia, arthroscopy, or even open shoulder surgery. Technology Overview: Patients suffering from frozen s...

Nanostructured Fibrous Membranes for Efficient Membrane Distillation

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 11:09:22 GMT

Nano-fibrous mats with tunable pore sizes and interconnected pores for integrated liquid and vapor phase membrane transition Background: Membrane distillation is a separation process in which separation occurs due to phase change across a barrier formed by hydrophobic membrane for liquid phase, allowing the vapor phase to pass through the pores. Technology Overview: Implementation of this process includes asymmetric wettability in order to induce directional liquid transfer through the membrane, after the completion of liquid phase transition. The use of nano-fibrous mats instead of c...

Natural Enamel

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 10:56:57 GMT

A method to produce natural enamel that minimizes microleakage with better esthetic acceptance Background: CAD/CAM (Computer-Aided Design and Computer-Aided Manufacturing) technology in dentistry provides a range of dental restorations including crowns, veneers, inlays and onlays, fixed bridges and dental implant restorations. The materials employed in this process, however, including metals, porcelains and composites, are characterized by remarkable discrepancies in mechanical properties compared to the natural teeth, such as hardness, elasticity and temperature coefficient...

Electrode Materials for Group II Cation Based Batteries

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 10:43:46 GMT

Magnesium is more abundant than lithium and is air stable, so magnesium batteries make a promising replacement for li-ion batteries Background: Batteries are described as an alternative technology to lithium batteries which are currently in widespread use. New proposed battery technology will have significantly lower environmental impact than the lead-based systems. Technology Overview: Magnesium batteries remain promising as possible replacements for lithium-ion batteries. Materials within new technology utilize new natural earth abundant material. Mangane...

Computer-Aided Detection and Differentiation of Lung Nodules

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 10:16:02 GMT

Computer-aided detection and diagnosis for identifying and differentiating between malignant and benign lung nodules Background: Lung cancer remains the number one killer in all cancer-related deaths in the United States. Virtual biopsy on detected lung nodules has been challenging due to the high prevalence of lung cancer and the difficulty of differentiating nodules. Computer-assisted detection of the nodules is also challenging because of the large volume of data that must be read by radiologists. This invention provides a way to differentiate nodules while also addressing the issues w...

Novel Method For Enzymatic Production of Cyclic-diGMP

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 09:47:46 GMT

Enzymes for synthesizing large quantities of cyclic-diGMP that are low cost and retain enzymatic activity for several months Background: Cyclic bis (3?,5?) diguanylate monophosphate or (cyclic-diGMP) is a bacterial secondary messenger involved in the regulation of various cellular processes that have medical and agricultural implications including biofilm formation, regulation of virulence factors, and cell mobility. There is also a growing interest in understanding the underlying mechanisms by which cyclic-diGMP regulates these processes in the scientific community. Current enzymatic met...

Ultra Low-Dose CT Image-Guided Intervention Using Previous Scans as Prior Constraints

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 09:41:18 GMT

System and methodology of performing low-dose CT images directly correlated with lowering the mAs parameter in data acquisition Background: It is well documented that the more X-ray CT imaging exposure time in a clinic, the more harm is caused to the patient. Low-dose CT is desirable in numerous clinical applications. Technology Overview: Low-dose CT images are directly correlated with lowering the mAs parameter in data acquisition and modeling the data property for statistical image reconstructions. Advantages: Algorithm is fully automated and extremely robust - Results are outs...

Hydrophobic Sponges for Oil

linda.galvin@stonybrook.edu — Thu, 27 Aug 2020 08:51:25 GMT

An oil recovery sponge with a natural absorbent substrate that is reusable up to 20 times, making it ideal for responding to oil spills Background: Oil recovery systems that use a sponge to soak up the contaminated oil may be reused and then may be disposed of because they become less efficient with subsequent re-use. Technology Overview: Researchers at Stony Brook University have created an oil recovery sponge which can be used 3 to 20 times without decreasing its efficiency of absorption. The sponge is a natural porous substrate (luffa sponge) treated with silicon material ren...

Novel Compounds and Methods for Treating Invasive Fungal Infections

linda.galvin@stonybrook.edu — Tue, 25 Aug 2020 11:50:53 GMT

Compounds that decrease the synthesis of glucosylceramide, a sphingolipid that promotes fungal infection Background: With the increasing number of immunodeficient subjects and the increase of the lifespan of these subjects due to the advance in medicine, there has been a concomitant rise in the number of cases of life-threatening fungal infections. Current antifungals are either static, toxic or/and with a too narrow spectrum of activity and increased use have led to increased drug resistance. Therefore, there is a need for new, safer and more effective compounds. Studies ha...

Method for Preparing Chemical/Surface Modified Nanocrystalline Cellulose

linda.galvin@stonybrook.edu — Tue, 25 Aug 2020 11:16:49 GMT

Inpart-Short description Background: There is a growing interest in the development of nanocomposites consisting of organic polymers and various nanomaterials. In general, composites have been used extensively in civil infrastructure applications and their use continues to grow in the new and existing structures via retrofits, rehabilitations, and repairs. The use of nanomaterials is revolutionizing the properties of the existing composites. Technology Overview: Scientists at Stony Brook University have invented a fast and scalable method of cellulose modification where a fast surface...

Alkene Isomerization as an Entry to Efficient Alternating Ring-opening Metathesis Polymerization (iAROMP)

linda.galvin@stonybrook.edu — Tue, 25 Aug 2020 11:02:28 GMT

A technique that enables the preparation of long length and low dispersion polymers with an alternating functional group arrangement Background: Most sequence-controlled polymers lack rigorous fidelity or are homopolymers with simple chain microstructures or copolymers, in which the monomer sequence is not precisely controlled. Polymers of imprecise sequence are widely employed, but do not provide the same structural and functional complexity as sequence-controlled biopolymers created by nature. This invention provides a facile approach to prepare extremely long and completely alternating...

Dynamic Phantom for fMRI

linda.galvin@stonybrook.edu — Tue, 25 Aug 2020 09:59:56 GMT

A dynamic phantom as a platform that minimizes MRI scanner noise for the development of computational neuroscience techniques. Background: Magnetic resonance imaging (MRI) is typically used to obtain detailed pictures of organs and tissues inside the human body. An MRI machine frequently includes a large tube-shaped magnet in which a patient lies down. When an MRI system obtains images of the brain, structures such as the brainstem, cerebellum, and the four lobes of the cerebral cortex can be seen. These structures are largely made up of nerve cells that carry electrical brain signals. Su...

Hybrid Electrolytes for Group II Cation Based Batteries

linda.galvin@stonybrook.edu — Tue, 25 Aug 2020 09:38:57 GMT

A hybrid electrolyte system with Group II cation batteries that are safer and have a lower environmental impact than lithium ion batteries Background: Lithium ion batteries and lead acid batteries are used as benchmark systems. Variation in the cost of specific batteries is dependent on factors such as design, manufacturing process and number of units. Technology Overview: Researchers at Stony Brook University have invented a new hybrid electrolyte system enabling the development of naturally abundant, low-cost materials with minimal environmental impact. The batteries described are ...

Highly Porous Fibrous Network Materials for Gas Filtration

linda.galvin@stonybrook.edu — Tue, 25 Aug 2020 09:12:09 GMT

A nanofibrous gas filtration membrane with tunable pore size and low pressure drop ideal for filtering fumes, viruses and particulate matter Background: Filtration is used to separate one substance from another by entrapment within or on a filter medium. Air filtration can be important in both industrial and personal applications, especially as pollution in certain areas becomes worse. A variety of pulmonary diseases, induced by serious air pollution, can cause numerous health problems, including death, in numerous people, especially the elderly and children. Therefore, in recent y...

Porous Graphene Based Composite Membranes for Nanofiltration, Desalination and Pervaporation

linda.galvin@stonybrook.edu — Tue, 25 Aug 2020 08:20:01 GMT

An ultra-thin barrier from a single atomic layer of graphene-based materials with adjustable pore size Background: For membrane separation technology, preparing a very thin barrier layer with high selectivity, high throughput, low fouling, and long lasting properties forms the ultimate set of goals, which the widely used polymeric materials have not been able to achieve. Two dimensional single atomic layer materials, such as graphene and graphene oxide, can be very competitive candidates for the proposed tasks, because there is a set of properties has been conceived for the ...

Elastic Membrane-based Membrane Bioreactor (MBR) with High-Efficiency for Fouling Control

linda.galvin@stonybrook.edu — Tue, 25 Aug 2020 07:34:10 GMT

A flat sheet elastic microfiltration membrane that improves fouling removal in bioreactors without the use of harsh chemicals Background: Membrane bioreactors are designed to remove contaminants from wastewater. This wastewater can come from residences, businesses, industries, and runoff water from rainfall and/or flooding. A membrane bioreactor (MBR) employs micro-filters (membranes). For currently available membranes, only the loosely attached foulants can be removed during the backwash process. By contrast, those particles, colloids and solutes that are comparable or smaller than the p...

New Polymeric Material for Cell Culture Devices

linda.galvin@stonybrook.edu — Tue, 25 Aug 2020 06:01:36 GMT

A treated particle with a dual layer coating for use in a variety of healthcare and cosmetic products Background: The electrochemical activation process is well known in the water treatment purification industry. RSS.HDTechnology> Technology Overview: < This invention relates to a treated particle having a core particle that is fully coated by a dual-layer coating. A hydrophobic polymer in the outer layer contains branched moieties that penetrate through the inner layer as to anchor said inner layer onto the surface of the core particle. Advantages: Technology incorporates ski...

The Addition of Graphene and Metal or Metal Oxide-Modified Graphene to Improve Organic Solar Cells

linda.galvin@stonybrook.edu — Mon, 24 Aug 2020 14:01:39 GMT

The addition of graphene or metal-graphene to organic polymer solar cells improves energy production without high silicon costs Background: Presently, organic solar cells are extremely expensive due to the materials used. Additionally, they are inefficient due to a large amount of energy lost in the production process. This discovery offers an improvement in both cost and efficiency. Technology Overview: Researchers at Stony Brook University have discovered that the addition of graphene and metal or metal oxide-modified graphene can significantly improve th...

Compact Spectrometer for X-rays

linda.galvin@stonybrook.edu — Mon, 24 Aug 2020 13:46:32 GMT

Cost-effective spectrometer focusing apparatus for portable X-ray imaging Background: An x-ray spectrometer is an optical device used to resolve and select different x-ray photon energies. The x-ray spectrometer operates by using a diffractive crystal. A von Hamos x-ray spectrometer includes an x-ray source defined by a rectangular slit, a cylindrical bent crystal, and a position sensitive detector located on a crystal axis of curvature. The von Hamos geometry permits the spectrometer to collect data over an energy bandwidth. Different crystals are used at different angular specifications...

System and Method for Computer Aided Polyp Detection

linda.galvin@stonybrook.edu — Thu, 09 Jul 2020 09:01:38 GMT

A method for automatic polyp detection in minimally invasive colon cancer screening Background: Colon cancer is a major cause of cancer related death in the United States; most forms arise in the form of benign polyps in the colon. Screening is advised for adults who are at average risk of developing, but many don't follow this advice due to the discomfort of traditional optical colonoscopies. Virtual forms of a colonoscopy (i.e. CT scans) have been proposed to have a minimally invasive method of screening for colon cancer; colon models have a complicated geometric and topological structure,...

High Efficiency Energy Generator for Harnessing Ocean Wave and Mechanical Vibration Power

linda.galvin@stonybrook.edu — Wed, 08 Jul 2020 08:31:37 GMT

An energy generating device utilizing rail deformation in a railway system. Background: The present invention relates generally to an apparatus for harnessing mechanical vibration power, and more particularly, an apparatus and method for generating electrical energy via unidirectional rotation by harnessing mechanical vibration. As compared to an ocean wave, water molecules follow an orbital path such that the surface of the water moves in a wave pattern periodically rising to a wave crest above a still water level and dropping into a wave trough below a still water level. This provides a ki...

Wireless Automated Meter Reading System

linda.galvin@stonybrook.edu — Wed, 08 Jul 2020 08:28:10 GMT

A low-cost wireless automated utility meter reading system for real-time utility monitoring Background: Single family residential structures will typically have one gas and one electric meter and may also have a water meter. Multi‑unit structures have numerous meters, such meters are provided by utility serving the structure and provide multi decade lifespan. Conventional meters provide a cumulative measurement of the amount of gas water steam or electric passing through respective meters. The responsibility utility renders a bill to the customer, and it is done through manually reading the ...

Silylation of Single-Walled Carbon Nanotubes

linda.galvin@stonybrook.edu — Wed, 08 Jul 2020 08:27:50 GMT

A non-destructive method to prepare semiconducting, silylated, single-walled carbon nanotubes Background: Single walled carbon nanotubes (SWNTs) possess unique structural, electronic, mechanical, and optical properties. The combination of the helicity and diameter of SWNTs, defined by the roll-up vector, that is, tube chirality, determines whether a tube is a metal or a semiconductor. One main motivation of understanding the electronic structure of carbon nanotubes is that as spatially constrained one-dimensional structures, they are the smallest dimensional systems that can be used for the ...

Semiconductor Laser Source with Electrically Tunable Emission Wavelength

linda.galvin@stonybrook.edu — Wed, 08 Jul 2020 08:25:51 GMT

A tunable semiconductor with novel wavelength adjusting technology Background: An adjustable semiconductor light source, such as lasers or light diodes, have a high demand for variable wavelengths in a controllable manner. Although there are methods to change the wavelength of a light beam, they are either impractical or uncontrollable. There is a need for an emission source which allows wide range electrical tuning of the emission wavelength for both laser and LED operation modes. Technology Overview: This tunable semiconductor is comprised of an optically active r...

Electric Toothbrushing Monitoring via a Magneto-Inductive Coil Sensor

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 11:26:18 GMT

Using a low-cost non-intrusive magnetic sensor for fine-grained electric toothbrush activity recognition. Background: Brushing your teeth is a daily task that is paramount for good oral hygiene. To improve the results of this task, many improvements have been made in the methods of brushing teeth and the toothbrushes themselves. One such improvement was the production of electronic toothbrushes. They use a motor to generate rapid automatic bristle motions that remove plaque, reduce gingivitis, and prevent tooth decay. However, the automated brushing mechanis...

Adapter for Surgical Retractors

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 11:18:03 GMT

Implementation of an adapter that allows for variability and ease of use of surgical retractors Background: There are many forms of surgical retractors, each of them having their advantages and disadvantages but there is a need for an adapter that allows for a plurality of friction grips on surgical retractors, or supported by a robotic arm. Based on the type of retractor, it can have a curved, hooked, or angled blade that is fitted with a handle. Technology Overview: This technology revolves around an adapter that is configured for use with handheld surgical retractors. It has a body...

High Speed 3D Facial Scanning System

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 11:04:33 GMT

A user-friendly, high speed, high accuracy, and portable 3D facial scanning system that can be implemented in a multitude of fields Background: 3D scanning techniques and technologies are continuously being implemented and improved in areas such as medical fields, movie industries, and gaming worlds. However, a significant obstacle within 3D scanning is acquiring dense and accurate mesh sequences. Conventional 3D scanning techniques do not adequately combat this obstacle, so there is a gap where substantial advancements can be made.3D scanning systems can be used for situations such as melanom...

Removal Process of Negatively Charged Impurities Using Metal-Cellulose Fiber Composite

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 09:17:37 GMT

Using a stable, predominantly positively charged, composite structure to separate negatively charged impurities from water Background: The process of removing negatively charged impurities such as fluoride, nitrate, nitrite, phosphate, sulfate, and other ions from water is necessary in order to effectively make cleaner water. There have been multiple processes and methods implemented to achieve this, however, there hasn’t been an appropriate balance between cost and efficiency. The most efficient processes are often the most costly and require materials that aren&rsquo...

Removal of Toxic Impurities via Metal Oxide Nanocrystals and a Cellulose Substrate

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 08:11:46 GMT

Using positively charged metal oxide nanocrystals anchored to a cellulose substrate to extract negatively charged impurities from water Background: The process of removing negatively charged impurities such as fluoride, nitrate, nitrite, phosphate, sulfate, and other ions from water is necessary in order to effectively make cleaner water. There have been multiple processes and methods implemented to achieve this, however, there hasn’t been an appropriate balance between cost and efficiency. The most efficient processes are often the most costly and require materials that are...

Systems and Methods for Self-Cleaning Solar Panels Using an Electrodynamic Shield

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 07:38:17 GMT

A transparent electrodynamic screen that automatically removes dust from solar panels and concentrators, increasing cleaning efficiency Background: Due to the extensive sun exposure, solar plants are usually located in semi-arid and desert regions; these also happen to be the dustiest locations in the world, meaning the equipment gets dusty very quickly. Dust adheres to solar panels, obstructing the cells from receiving radiation. This also reduces energy conversion significantly; just 4 grams of dust deposited per square meter of a solar panel may reduce power output by 40%. Current method...

Process for Visual Analysis of Dominance Hierarchies

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 07:18:28 GMT

Using a visual analytics system to inspect the formation, maintenance, and relationships of dominance hierarchies in small groups Background: Interaction among group members results in the formation of social groups which can then be studied to understand the status of the members, decision making behaviors, spread of knowledge and diseases, and more. A defining characteristic within groups is the hierarchy of its members, and there is a need for tools and a process to understand the formation and maintenance of these hierarchies. Even though online social groups and social networks have ...

Real-time Detection and Reconstruction of Advanced Cyber Attack Campaigns from Host Event Logs using Provenance Tags and Customizable Policy

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:51:17 GMT

A system and method for identifying cyber attacks and events and reconstruction thereof with improvements in efficiency Background: Cyber security has grown to be a more complex field as technology evolved. Cyber attacks (or CNAs, computer network attacks) are an exploitation of computer systems or networks and often use malicious coding to alter data. This can lead to various cyber crimes, like identity or information theft. Currently platforms for cyber security are really well equipped to detect concrete indicators of compromise (IoCs), but aren't so great at detecting the root cause of u...

Solderless Circuit Connector

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:50:07 GMT

Surface mount connector that allows for repeated mounting and unmounting of electronic components with densely populated pinless terminals Background: Over time the size of integrated circuits (ICs) have decreased, but with this, the number of circuits per package has increased (and continues to). It's necessary to facilitate communication between the elements of the circuit and the outside system. Terminal leads are becoming finer, meaning they're more difficult to mount on printed circuit boards (PCBs). Packaging technology has evolved into leadless packing in order to address thi...

Nanofibrous Materials for Heavy Metal Absorption

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:48:42 GMT

Water filtration membranes with polysaccharide fibers that allow for binding of heavy metal ions Background: Agriculture and manufacturing methods have caused large-scale heavy metal ion (lead, arsenic, mercury, etc.) pollution. This is a major public safety issue for drinking water, since these pollutants can contaminate rivers and lakes. Public safety issues can include symptoms like headache, abdominal pain and irritability; larger exposure can lead to more serious issues such as respiratory, kidney or liver damage. Exposure can even lead to problems like pregnancy loss or immunological s...

Graphene Laminate Structures

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:47:29 GMT

Compositions and architectures (with production methods) having improved mechanical strength, optical transparency, and electrical mobility Background: Laminate glass films suffer from an inherent trade off between the strength, weight, and optical transparency. Ballistic and blast protection can be improved by adding thicker or additional layers of glass or plastic, but at the expense of reduced optical transparency and increased physical weight. New materials are desired that, when incorporated into standard architectures, yield higher optical transparency for the same protection. Technol...

Discovering Causal Relationships in Multivariate Datasets

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:45:49 GMT

Interactive 2D data analytic graphing software that allows users to verify and edit causal links and identify a valid causal network Background: One of the major aspects of analytics involves identifying and determining causality relations in a multivariable set of data. However, conventional methods to do this are not effective in processing colossal amounts of data sets and being precise due to the fact that the algorithms assigned to do this cannot encode an adequate amount of domain knowledge. Although tedious, a visually analytical approach can be implemented as an alternative to fully...

Removal of Nitrogen Impurities and Retrieval of Ammonium Salts from Contaminated Water

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:44:38 GMT

Economical, efficient, and quick process to remove nitrogen impurities and recover ammonium salts from wastewater Background: A major challenge for wastewater treatment plants is to find processes that effectively, quickly, and economically remove contaminants/impurities from waste water. This obstacle has steadily become increasingly difficult as the Environmental Protection Agency implements more stringent requirements and restrictions on water filtration. The most common procedures used for this case are precipitation of certain materials, filtration, sedimentation, and ion exchange. How...

Computer Mouse Modifications for Visually Impaired Users

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:43:15 GMT

Alterations to computer mouses that allow easier and expedited user input and navigation of a computer screen by haptic feedback Background: A conventional computer mouse is composed of a curved palm-rest, at least one motion sensor for detecting movement of the mouse, and several selection push-buttons. The user will push down on the palm rest to move the mouse, which results in a downward movement of the user's wrist. Also, the distal phalanx of at least one finger will be rested on the selection push-buttons which inadvertently causes the part of the palm closest to the wrist to be unsupp...

Applications of Quantum Physics in the Storage, Transmission, and Processing of Information at Room Temperature

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:39:35 GMT

Quantum network devices, systems, and methods that are used in various quantum communication applications Background: Quantum communication technologies have the potential to completely change how information is stored, transmitted, and processed. This is due to the fact that it can enable 100% fully secure communication lines between communicators. This is possible because, contrary to cryptographic communication which uses mathematical functions that can be cracked, quantum communication uses quantum physics to communicate information. It is impossible to eavesdrop on a quantum communicati...

Novel Continuous Treatment of Wastewater by the Addition of Recyclable Propane Gas

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:37:05 GMT

Separating impurities from wastewater via a phase change caused by the addition of propane gas under mild pressure and low temperatures. Background: Wastewater management is an issue that is increasingly requiring more immediate attention as the freshwater crisis expands globally. The current processes implemented in the U.S. account for 2% of total U.S. electricity. Publicly owned treatment works (POTWs) operations resulted in energy-related emissions which then led to a total emission of 15.5 million metric tonnes of carbon dioxide in 2000. Additionally, in 2012 the U.S. spent 102 billion ...

Using Algorithms to Identify Fractures in Digitized X-rays

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:34:36 GMT

Combination of algorithms that use local geometry, edge detection, and advanced image processing to recognize fractures in digital x-rays Background: One of the most common reasons people go to any medical office is due to musculoskeletal injuries. X-rays are the first line imaging tool for musculoskeletal injuries, and are performed to determine the type of injury and location. After the x‑ray, a physician or radiologist will inspect the x‑ray to see whether there is a fracture or not. Some fractures have a very notable displacement of the fracture fragment from the bone so it is often obv...

Maximizing Convolutional Neural Network (CNN) Accelerator Efficiency Through Resource Partitioning

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:25:08 GMT

A new CNN accelerator that achieves a 3.8x higher throughput than the state-of-the-art accelerators by using multiple processors Background: Convolutional Neural Networks (CNNs) are revolutionizing the field of machine learning, being used in areas such as recommendation systems, natural language processing, and computer vision. However, they have computational challenges that need to be accounted for through the use of accelerators. Improvements to these CNN accelerators are being made consistently every year, however, as improvements have rapidly increased, so has computation cost and the ...

Real-Time Multi-Tag Tracking Process Via a Single Magnetometer Sensor

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:23:30 GMT

Magnetic tags worn by drivers to track and classify their head movements through the use of analytical and approximation sensing models Background: Every day in the U.S., there are 9 deaths and 1,153 injuries caused by drivers who are distracted behind the wheel. Data from the National Highway Traffic Safety Administration shows that 94% of all car accidents are a result of a driver’s failure to follow safe driving guidelines due to manual and visual distractions, and drowsy driving, Thus, many car collisions can be prevented if there was a way to detect these unsafe driving b...

Scintillating Substrate Compositions and Coatings for Dual-Screen Flat-Panel Detector Improvements

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:15:42 GMT

Using light-scattering glass-ceramic scintillators to increase the sensitivity and detective quantum efficiency of flat-panel detectors Background: There is a need for improvements in diagnostic imaging devices that are utilized in various clinical applications. Two notable clinical applications where detectors have a relatively poor performance are cone beam computed tomography and image-guided surgery. There has to be a balance between cost and efficiency, and there is a demand for a detector system that can adequately balance both. One specific example of a present need in the market woul...

Ultra-Low Power Core for Lightweight Encryption

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:12:45 GMT

Using a bit serialized, ultra-low power SIMON core that leverages adiabatic switching to provide cybersecurity via the form of encryptions Background: The exponential advancement of the internet, coding, and devices that embody both have led to a term known as ubiquitous computing. This term basically means that computing can be done anywhere, on a multitude of devices, in multiple formats; this is also evident as smart fridges, smart TVs, automated lights, and etc have started to increase. As one can expect, the continued growth of ubiquitous computing will have a big influence on areas su...

Novel Approach for Processing Brain Images and Extracting Neuronal Structures

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:07:59 GMT

Using a distance transform algorithm for the meaningful visualization of wide-field microscopy (WFM) brain images Background: Understanding neural connections that depict brain function is paramount to neurobiology research. There are advances in microscopy technologies that have furthered this research via the study of biological specimens. Using optical and electron microscopes to obtain high-resolution images allowed the retrieval of the micro and nano scale 3D anatomy of the human nervous system. Confocal microscopes have also been used for this purpose. However, these microscopes are e...

Method and Apparatus for Passive Wireless Channel Estimation in Radio Frequency Network

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 06:01:24 GMT

For estimation of wireless communication channel characteristics between (at least) two passive radio frequency nodes using BCSI measurement Background: Radio frequency Identification (RFID) tags usually exist as either active or passive tags; active tags have an actively powered transceiver, while passive tags are powered through harvested ambient energy. Passive tag-to-tag communication is a relatively new desirable technology. Efforts to advance this technology have been made through electromagnetic models. These efforts aimed at improved range of tag-to-tag link, improved hardware for t...

Supervised Machine Learning - Based Method of Data Analysis of X-Ray Absorption Fine Structure Spectra

linda.galvin@stonybrook.edu — Tue, 07 Jul 2020 05:55:45 GMT

Implementing supervised machine-learning to various materials' spectroscopy data to gain more insight on the structures of those materials Background: A multitude of methods can be used to analyze the structures of various materials and gather information about them. One of those methods includes first reviewing the numerous spectra of the materials and then making conclusions on the material itself. Two spectra that are commonly looked at are X-ray absorption spectra (XAS) and Electron energy loss spectra (EELS). X-ray absorption spectroscopy is used to discover the local atomic and e...

Surface Coating on Nanofibrous Scaffolds by Interfacial Polymerization for Ultrafiltration and Desalination Applications.

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 13:16:55 GMT

A fibrous support comprising nanofibers for increased flux rates and reduced fouling rates in filtration Background: There is an increased need for filtration methods for obtaining fresh water due to a depleting supply. Typically, technologies such as nanofiltration, ultrafiltration, and reverse osmosis have been used to treat water. Conventional membranes for water filtration have top layer coatings made through interfacial polymerization. The membranes that are currently commercially available have been effective in treating water, but have several drawbacks, including low flux and ...

System, Method, and Computer-Accessible Medium for Virtual Pancreatography

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 13:14:35 GMT

A novel process for virtual pancreatography using computer-aided diagnosis ("CAD") Background: Pancreatic cancer is potentially one of the most fatal cancers; it has an overall five-year survival rate of less than 9%. This is due to poor prognosis, and because it has no specific early symptoms. However, detecting precursors of pancreatic cancer offers the chance to prevent its development. The presence of pancreatic cystic lesions can indicate precursors of this cancer. Current imaging technology, like computed tomography (CT) and magnetic resonance imaging (MRI), can easily detec...

System, Method and Computer-Accessible Medium for Ultralow Dose Computed Tomography Image Reconstruction

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 13:13:24 GMT

Use of systems to create a higher quality, more accurate image Background: Computer tomography (CT) currently operates at high X-ray exposure, in terms of high X-ray flux. These images provide key details into warning such as potential lung cancer in smoking patients, or even possible birth defects in children. However, there are still challenges in obtaining quality radiological images while using lower and therefore, safer levels of radiation. Thus, it may be beneficial to provide an exemplary system, method and computer-accessible medium for ultralow dose computed tomography (ULDCT) image...

Fabrication Method for Fused Multi-layer Amorphous Selenium Sensor

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 13:12:29 GMT

This novel technology uses blocking layers to dampen electronic noise and the effect on imaging, for improved optical and x-ray sensing Background: Amorphous selenium (a-Se) has been commercialized both as an optical sensor and direct x-ray detector, and a-Se with avalanche gain has also been proposed for use in an indirect x-ray detector. Advantages include the capability for large area deposition, avalanche multiplication of holes at electric fields (ESe) greater than 70 V/um, and monotonically increasing x-ray conversion gain with ESe. However, traditional a‑Se detectors suffer from im...

High Flux Ultrafiltration and Nanofiltration Nanofibrious Membranes Containing Cellulose Coating by Ionic Liquids

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 13:07:51 GMT

An improved, cost-effective, and non-toxic separation membrane for oil/water emulsions and several fluid separation systems Background: Conventional composite membranes currently run into the issue of pore blockage when soaked in amine solutions. The clogged pores create increased coating thickness, which decreases the flux rate. Cellulose is being considered for use in these membranes. It's an abundant, renewable, and cost-effective material; however, it has poor solubility in common organic solvents, limiting its applicability. Despite this, cellulose can offer improved properties due to i...

Ultra-Nanofibers for Air and Water Filtration

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 13:05:55 GMT

This technology is a membrane of polysaccharide nanofibers and an electrospun substrate, with applications in water filtration Background: Using cellulose nanofibers for water filtration can be advantageous due to the functionality of their surfaces; they can be adjusted to guide water flow inside water channels or to selectively alter the adsorptive or repulsive properties for particulate separation. They can be prepared from natural plants after chemical and mechanical treatments. These fibers have smaller diameters and can be modified at their surface. The current method...

Flat-Panel Detectors with Avalanche Gain

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 13:02:31 GMT

Use of photons to create an electrically charged matrix and produce higher quality images Background: Active matrix flat-panel imagers (AMFPI) based on active matrix thin film transistor (TFT) arrays are the most promising technology for digital x-ray imaging due to their compact size, rapid readout, and better imaging performance than screen films. Technology Overview: A flat panel detector, comprising of a phosphor screen for receiving x-rays and converting the x-rays into optical photons, produce electrical charges from the photons and create an active matrix for detecting electrical ch...

Carbon Nanotube Sensor of Icing and Humidity

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 12:59:52 GMT

A method of production for a carbon nanotube (CNT) sensor using an acidic solution, temperature control and filtration Background: Conventional systems for sensing moisture use a Loop Powered Dewpoint Transmitter (LPDT). The LPDT system lets a user monitor the operation of a sensor constructed as a capacitor in order to view dewpoint. This capacitor usually has a dielectric consisting of porous aluminum oxide. The user can monitor the gas entering the pores of the aluminum oxide as well, in order to view dewpoint. Aluminum oxide keeps capacitance constant; capacitance varies through adsorpti...

Device for Rapid Simple and Highly Parallel Single-Cell Processing Including Spatial Analaysis

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 12:54:10 GMT

An innovative device based on a modified array of microwells representing the next-generation of single-cell and spatial genomics platforms Background: Technologies for preparing samples for single-cell genomic applications have revolutionized the way scientists interrogate tissues by enabling the detailed deciphering of their composition. Recently, similar approaches have been developed to maintain the spatial information of the cells analyzed. Despite their successes, this first wave of methods and devices suffers from technical shortcomings that limit the quality of the data generated. P...

EXOMERA: Extracellular Vesicles Purifier and Analyzer

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 12:47:05 GMT

Automated tool for isolation of intact extracellular vesicles with near-single-vesicle resolution coupled with in-line characterization Background: Extracellular vesicles (EVs) are sub-micron sized membranous vesicles secreted by most cell types and wind up circulating in body fluids such as blood and seminal plasma. In the past decade, EVs have gained huge attention for their prognostic and diagnostic potential, as well as their drug delivery prospects. However, progress has been hindered by the lack of a system that efficiently purify EVs from complex biological samples such as blood and ...

High-Flux Thin-Film Nanocomposite Reverse Osmosis Membrane for Desalination

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 12:43:11 GMT

Use of nanofiber composites to create a higher filtration rate in reverse osmosis for energy efficient separation Background: Reverse osmosis (RO) is one of the most energy efficient separation technologies to remove salt ions from brackish water or seawater. Conventional RO membranes possess a thin film composite (TFC) structure, containing an ultra-thin barrier layer. This layer can be used as a filter. However, nanofillers may be incorporated into the polyamide barrier layer to improve either the permeability or separation efficiency when separating materials. Technology Overview: Using...

Nanoparticle Sensor Having a Nanofibrous Membrane Scaffold

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 12:38:58 GMT

Novel nanoparticle sensor with applications in sweat detection for medical monitoring. Background: Perspiration contains useful medical information on physical conditions for those living in environments with high temperatures, or for those who engage in physical activity for extended periods of time. Because of this, there has been an increase in demand for the development of wearable sweat sensors. Progress has been made thus far, but challenges are present, such as lack of multifunctionality, biocompatibility, and flexibility. Also, they're high-cost and have insufficient sensitivity. Te...

Novel Bio-hybrid/Bio-functional Materials

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 12:24:06 GMT

A novel method of encapsulating microbes within crosslinked electrospun hydrogel fibers that maintain their viability. Background: Electrospinning is a process where interactions between an electrostatic field and a fluid are utilized to form nanoscale and microscale polymer fibers. These fibers can be collected to form an interconnected web of fibers, or a film. These films have large surface area to volume ratios, high permeability, and small pores; these qualities make them ideal for containing bacteria. Previous attempts to encapsulate microbes in nanofibers involved bulk immobilization ...

Dual-screen Digital Radiography with Asymmetric Reflective Screens

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 12:15:56 GMT

This novel radiography technology uses dual screens to project a clearer image of an object. Background: In digital radiography, an imaging system may include a screen that absorbs radiation and produces light, where the produced light is sensed by an array of photosensors to generate electrical signals. The generated electrical signals may be used by the imaging system to produce a digital image. In some examples, a quality (e.g., sharpness, resolution) of the produced image may be affected by various phenomena such as light scattering, and/or other phenomenon. Technology Overview: The t...

Bolometric Sensor with High TCR and Low Resistivity

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 12:13:09 GMT

The invention provides a novel way of operating bolometers in the resistive hysteresis region of a phase-transitioning VO2 film. Background: Visualization of infrared (IR) radiation is achieved by projecting an IR picture onto a sufficiently large 2D matrix of small microbolometers. Using electrical signals, outputs can be visually displayed, thus creating a pixelated image of the original IR picture. One of the issues resolved by the technology relates to the sensor material and its electrical resistance as a function of temperature. Technology Overview: The technology is a bolometric sen...

System and Method for Occupancy-Driven Register Airflow Control

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 12:08:43 GMT

Active monitoring of heating, ventilation and cooling (HVAC) systems for energy efficiency. Background: HVAC is the largest source of building energy consumption. Therefore, energy - and consequently money - can be saved by closing off air vents during certain hours of the day. These are so-called smart vents. However, these products do not have on-board sensors, and therefore are not efficient. There needs to be an efficient, cost-effective way to monitor the status of HVAC systems, and organize processes in a manner impact to office spaces. Technology Overview: Researchers have developed...

Titania and Titanate Nanostructures (BNL 15-26)

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 12:05:38 GMT

A method of synthesizing titanate and titania nanostructures and assemblies of them with controlled properties Background: Traditionally, synthesis of nanomaterials has relied on a number of imperfect approaches, like "top-down" and "bottom-up" methods. These methods are limited in terms of available shapes and sizes for the construction of nanomaterials. The chemical structure of nanomaterials could be controlled more efficiently if one could begin with nanoscale precursors. Nanocrystallites of TiO2 (titania) have electronic, optoelectronic, and catalytic propertie...

Apparatus for Electro-Blowing or Blowing-Assisted Electro-Spinning Technology and Process for Post Treatment of Electrospun or Electroblown Membranes

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 12:01:10 GMT

Use of electrospinning and melt-blowing processes for a higher yield, more efficient production method of fiber manufacturing. Background: Electrospinning is the process where an electrostatic field is strong enough to overcome the surface tension of a liquid. This process allows nanofibers to have a very large surface area to volume ratio, thus having many applications in areas such as filtration and molecular protection. However, the largest technical issue with the process is when fabrication size becomes small. When the fibers required become smaller in both physical dimension and volume...

Applications of M-plane (1-100) 15R-Silicon Carbide and Related Substrates to Eliminate Defects in Epitaxial films

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 11:56:04 GMT

A method of epitaxial growth of SiC substrates for use in semiconductors and other SiC devices Background: Products can be fabricated using epitaxy; this is a process where a crystalline layer is deposited on a crystalline substrate. Semiconductors can be fabricated through this method. Silicon Carbide (SiC) is a crystalline material existing in various forms (polytypes): that is, these forms differ in physical arrangement but do not vary in stoichiometry. Previously, epitaxial layers have been grown using the polytype 15R-SiC, but this substance is not commercially available in large quanti...

Method for Removing Strongly Adsorbed Surfactants and Capping Agents from Metal to Facilitate their Catalytic Applications

linda.galvin@stonybrook.edu — Mon, 06 Jul 2020 11:52:15 GMT

A method of synthesizing activated nanostructure electrocatalysts without damaging their surfaces. Background: Certain metals (like Pt, Pd, and Ru) are known as excellent electrocatalysts (catalysts in an electrochemical reaction), but they're also costly and scarce. They're also susceptible to carbon monoxide, have poor stability under cyclic loading, and have slow reaction kinetics for the oxygen reduction reaction. They also have to be activated without damaging the surface of the particles. An approach to address this issue is forming metal nanoparticles; this requires proportionally hig...

Nanocomposite HA-Clay Based Hydrogels

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 17:01:20 GMT

A hyaluronic acid-clay based hydrogel, with applications for cell culture scaffolds in tissue engineering. Background: An approach to tissue engineering includes mimicking the environment of tissue development _in vivo_; this includes the two components of a scaffold and a bioreactor. A scaffold is inserted into a bioreactor, which provides conditions that are similar to _in vivo_ conditions. Scaffolds need to meet specific requirements in order to facilitate cell seeding and diffusion; such requirements include high porosity, adequate pore size, biodegradability, and injectability. Hyaluron...

Dual Function Ag-Lio-I Based Battery

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:59:43 GMT

Use of lithium/silver composite structures to create self-restoring cells in batteries. Background: Lithium ion batteries have powered many important devices during their development over the past several decades, such as pace makers and other bio-medical devices. Devices such as these are very reliant on lithium batteries because they are able to be used for a long duration of time, can withstand a multitude of physical apparatuses, and do not relay on charge very often. However, batteries are able to be improved further, with the addition of new elements. Technology Overview: Researchers...

Modular Control of a Bioorthogonal Ligation

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:57:44 GMT

Caged cyclopropenes that are unreactive until activated for controlling bioorthogonal reactivity Background: Significant effort has been devoted to optimizing and discovering bioorthogonal reagents that are faster, fluorogenic, and orthogonal to the already existing bioorthogonal repertoire. Conversely, efforts to explore bioorthogonal reagents whose reactivity can be controlled in space and/or time are limited. The ?activatable? bioorthogonal reagents that do exist are often unimodal, meaning that their reagent?s activation method cannot be easily modified to enable activation with red-shi...

NanoSulf TM Process for Effective Sulfur Removal

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:54:45 GMT

Cost-effective and novel process to remove foreign substances and impurities within contaminated gas streams Background: There is an increasing global demand for sources where methane can be extracted and used to produce power, chemicals, and transportation fuels. One of the biggest sources for this purpose are landfills as they contain feed stocks, animal waste, bio-gas, etc. However, combined with the methane there is also sulfur, or hydrogen sulfide (H2S), which needs to be removed to extract just the methane. Depending on the concentrations, hydrogen sulfide can lead ...

Modular Robot Design and Prototyping Kit

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:52:05 GMT

Use of clip connectors to promote design driven robotics education Background: Traditional robotics for educational use often uses tools and machinery. Such needs limit where students are able to learn robotics. Along with limiting area, it is not cost efficient to provide every single student with the necessary tools (such as trills and a number of screws) to create a robot. The SnappyXO uses connectors that do not require tools, and can be easily manufactured to provide a large number of students the opportunity to learn robotics. Technology Overview: Using a variety of manufactur...

Quantum True Random Number Generator

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:49:37 GMT

Using a light sensor and photon channels to create random numbers. Background: Random numbers are typically necessary in everyday life: mobile communications, online payments, e-banking etc. In a time where almost everything can be done online, there is an unmet need for the generation of true random numbers at rates higher than 1 Gbit/sec. However, higher Gbits/sec are costly and are limited in outputs. Technology Overview: Exemplary embodiments of the present invention can provide a true random number generator. The exemplary true random number generator includes a light source configure...

Chopped Passive Infrared Sensor Apparatus and Method for Stationary and Moving Occupant Detection

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:45:25 GMT

Additions of multiple different elements to improve current PIR sensors. Background: Passive infrared (PIR) sensors are used in a variety of applications. They work by using the pyroelectric effect: a change based on the temperature modifies the positions of the atoms. However, because voltage is generated by pyroelectric materials, conventional PIR sensors are unable to detect stationary objects. Technology Overview: In order to detect stationary objects, new sensors would include a sensing element and a Fresnel lens disposed over a surface of a sensing element. Also included is an optica...

Field-Shaping Multi-Well Avalanche Detector for Direct Conversion Amorphous Selenium

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:42:38 GMT

The detector provides stable avalanche multiplication gain in direct conversion amorphous selenium radiation detectors. Background: Conventional micropattern gaseous detectors were developed to improve position resolution. However, the range of radiation induced photoelectrons is micrometer to millimeter in, with gas solid-state detectors having three-orders-of magnitude shorter photoelectron range due to their much higher density. Thus, solid-state detectors yield images with substantially higher spatial/temporal resolution. Disordered solids, which are easier and less expensive t...

Landscape Emulation and Locomotion Development through Virtual Reality

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:40:59 GMT

A system for generating a progressive representation associated with surjectively mapped virtual and physical reality image data. Background: Virtual reality (VR) creates an illusion for the user; typically it puts them in an artificially created world. VR may be achieved through stimulating senses that already occur in the user, such as sight and sound. The computer translates the actions of the user to affect the virtual environment they are in. Users are immersed into scenarios where they may not be physically able to be placed in such as a mountain terrain. However, a major limitation is...

Nano-electrode Multi-well High-gain Avalanche Rushing Photoconductor (NEW-HARP)

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:38:16 GMT

An amorphous selenium radiation detector that overcomes disadvantages of conventional detection methods Background: Amorphous Selenium (a-Se), previously developed for photocopying machines, has become commercially used in x-ray photoconductors for Flat-Panel Detectors (FPDs). However, current FPDs are limited by degradation of low-dose imaging performance due to electronic noise. The energy required to generate an electron-hole pair in a-Se is extremely high and unreliable to constantly reproduce perfectly. Technology Overview: This technology is a Time of flight (TOF) detector including ...

Machine Learning Methods and Software for Quality Control of Digital Pathology Microanatomic Segmentation

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:36:08 GMT

This system is based on dividing the image into patch level texture features which are then the basis of the quality assessment Background: Segmentation of nuclei in whole slide images is a common methodology in pathology image analysis. A variety of anatomical segmentation methods have been developed to detect the location of nuclei and other cellular structures. Achieving accurate and robust segmentation results remains a difficult problem because of image noise. Therefore it is necessary to have a quality control stage to assess the quality of segmentation results before the results...

Embedded Conformal Electronics and Sensors Via Novel Additive-Subtractive Fabrication Technology

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:32:21 GMT

Continual monitoring of machine parts for more efficiency using thermal spray technology coupled with precision laser materials Background: Engineering systems are becoming incredibly complex and efficient. However, as a result of these very powerful machines, when components break it is very expensive. There is also no central monitoring system for the components, thus lowering efficiency of machines over a period of time. Therefore, machines need to be monitored to schedule repairs at opportune times. Technology Overview: Thermal spray technology coupled with precision laser materials ov...

Enhanced Virtual Navigation and Examination

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:30:05 GMT

Use of voxels to create a more accurate image, using 2D visualisation to highlight missing attributes of the imaged system Background: 3D imaging has been a breakthrough in the analysis of an object, particularly in healthcare analysis. However, current 3D imaging requires manual input of information, for example, a specific bounded region, thus making the 3D image inaccurate. Along with that bias, current 3D imaging removes anything within said system, such as bodily fluids. Although there are protocols to have such fluids removed, it is unpleasant and prevents system users from taking exam...

Bioabsorbable Membrane for Prevention of Post-Operative Adhesions

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:27:15 GMT

A scaled-up method for fabrication of these fibrous articles for use in adhesion reduction and controlled delivery systems Background: Biodegradable and/or bioabsorbable fibrous articles have been fabricated previously. They have many useful medical applications, such as preventing post-surgery adhesion. A method of producing these fibers is through electrospinning. This is an atomization process of a conducting fluid which utilizes the interactions between an electrostatic field and the conducting fluid. Electrostatic atomization results in fibers with large surface areas and ...

Method For Treating Lateral Epicondylitis Using Collagenase

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:24:59 GMT

Collagenase injection for several syndromes that provides a minimally invasive and simple treatment option Background: Carpal tunnel, plantar fasciitis and lateral epicondylitis all have existing treatment methods; these methods tend to be invasive and disruptive. Carpal tunnel (a syndrome that causes tingling or numbness in the fingers) is typically treated through conventional or surgical methods. Conventional methods include anti-inflammatory medications, splinting, or corticosteroid injections, while surgical methods include endoscopies or open surgery. Plantar fasciitis is the inflammat...

Radiation Therapy with Orthovoltage X-rays and a Special Collimator

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:19:58 GMT

Method of therapeutic radiation delivery for a specific target using a multi-aperture collimator within a trajectory of orthovoltage x-rays Background: Current radiation therapy is carried out using mostly high energy x-rays. The current MeV x-rays being used have good qualities such as high tissue penetration and a skin-sparing effect. Despite this, several drawbacks are associated with this method; most importantly, the tissue surrounding the target receives radiation, which is damaging to the tissue. These high energy x-rays interact in a scattering mode rather than a photoelectric one, w...

Cell Regeneration Using X-Ray Micro Beam Irradiation and Administering Schwann-Cell Precursor Cells

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:18:39 GMT

Treatment of damaged nerves using x-ray radiation therapy with an in-beam dose sufficient to initiate demyelination Background: Mammalian peripheral nerves can be injured by a variety of ways including mechanical, radiation, and damage caused by the immune system. Peripheral nerves are located throughout both the Central Nervous System (CNS) and Peripheral Nervous System (PNS), however, the PNS is quite different from the CNS. Myelin is a mixture of proteins and phospholipids forming an insulating sheath around nerve fibers, thus increasing the speed at which impulses are conducted. Myelin i...

Novel Method to Compute with Wireless Energy

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:16:50 GMT

Conversion of AC signal to DC voltage without significant energy loss Background: A conventional wireless energy harvester receives ambient electromagnetic waves via a connector, and converts the alternating power into a direct current (DC) power supply. However, this introduces a problem: converting a harvest AC signal to a DC supply voltage results in a significant energy loss due to low power efficiencies of the rectification process. Thus it is not practical. Technology Overview: A passive charge recovery logic circuit that includes an electromagnetic field capturing device that harves...

System and Method for Dual-Use Computed Tomography for Imaging and Radiation Therapy

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 16:03:46 GMT

Use of microbeams to graph an area for therapy and tracking of radiation beams Background: In radiation therapy, the location of an area needed to be treated is crucial. Accuracy prevents damage to healthy tissue. The accuracy of launching radiation is based off of the accuracy of the tomography of the body. However, previous tomographic arrays limit their accuracy because of the lack of rotation within the gantry, thus increasing the risk of radiation in healthy cells. Technology Overview: Delivering microbeam radiation therapy (MRT) includes a computed tomography scanner configured to ge...

Graphene Oxide-Based Composite Membranes for Energy Efficient Ethanol Dehydration

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 15:54:14 GMT

A pervaporation membrane for energy efficient alcohol purification, such as ethanol dehydration Background: Biofuels, such as ethanol, are in high demand, especially since the United States began using ethanol as an additive to gasoline. Ethanol can be obtained through fermentation of suitable biomass using distillation processes. These processes are based on differing boiling points of ethanol and water. The goal is to minimize the water content in ethanol so that the gasoline and ethanol mixture is anhydrous. The final step in the dehydration process is expensive, energy inefficient, and r...

System and Method for Ranking Academic Institutions and Programs

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 15:47:28 GMT

Objective measuring of academic programs using higher volume of variables. Background: Various publications, organizations and individuals rank Universities and Graduate Schools. The rankings are typically used as tools by administrators to assess the quality of their programs and universities, and by students to determine which Schools and programs to make applications to. Existing methods for ranking universities utilize census forms distributed to faculties. Faculty members rank universities and programs according to their impressions. These impressions may be based on any number of...

Innovative Dental Local Anesthesia Retractor

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 15:41:05 GMT

More accurate, more comfortable, and safer dental local anesthesia injections Background: Despite the risk of needle stick injuries to the dentist, the administration of local anesthetics in dentistry often entails the use of the non‑dominant hand as an intraoral retractor (instrument to move, cover, and protect tissue). The dentist palpates (feels) the area of the injection and will often then keep finger(s) in the oral cavity to maintain tension on the tissue, and orientation with landmarks (known anatomic structures). Specifically, when the inferior alveolar nerve block is administere...

Prevention of Glucocorticoids-Induced Muscle Atrophy and/or Enhancement of Muscle Regeneration Via Neutrophil Elastase Inhibition

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 15:31:27 GMT

A novel therapeutic approach to treating muscular dystrophies by enhancing muscle regeneration, function and fiber size Background: Muscular dystrophy encompasses more than 30 inherited diseases characterized by muscle weakness and muscle loss. All forms of muscular dystrophy are progressive and deteriorating. At the moment, there is no cure for muscular dystrophy. Available treatments aim to alleviate symptoms and prevent complications. Low dose corticosteroids such as prednisone may help to maintain muscle tone however there are serious side effects associated with the long term use of th...

Producing Segmented Metallic Nanostructures and Homogeneous Metallic Nanostructures

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 11:52:57 GMT

An ambient, surfactantless, template-based method for reliable production of 1D nano-structures Background: 1D nano-structures have garnered significant and growing attention in the literature recently, owing to their diverse properties that are uniquely dependent upon not only size but also morphology. 1D nano-structures have distinctive optical, thermal and electronic properties made possible by the composing noble metals, rending this class of materials as attractive. Technology Overview: The technology is a method of producing a segmented 1D nanostructure comprisin...

Proton Computed Tomographic Image Reconstruction from Curved Paths

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 11:50:32 GMT

Computerized image reconstruction, specifically paths of proton particles, applicable to radiation therapy for cancer patients Background: Computed tomographic image reconstruction has typically focused on X-rays or photons in the body. This has become an increasingly popular way for radiation therapy for cancer treatment. Proton beams are better than X-rays and photons because they are 1) more accurate 2) leave other tissue unharmed 3) lower-cost. However, protons are heavy, thus bend when shot into the body. Therefore, imaging of the beam may not be accurate. There is a large portion of un...

Attachment of Conducting Graphene Electrode Layer to Solar Cells

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 11:48:02 GMT

Graphene oxide and an active layer of a polymer solar cell provide improved industrial production of longer-lasting, cost-effective cells Background: Renewable energy has been a topic of discussion for the past decade, especially since nonrenewable energy sources are steadily decreasing. Solar energy and windmills have been implemented in various places but have shown little promise in substantially combating the energy problem. There aren’t enough areas of improvement in wind energy as there are in solar energy, so there is a need for more efficient use of solar cells.Conventional...

Metal Phosphate Nanostructures

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 11:43:39 GMT

A method for producing crystalline metal sulfide nanostructures using a porous membrane and separate metal and sulfur precursor solutions Background: Recently, high-quality semiconducting nanostructures have been considered as model systems for transporting electrons and optical excitations efficiently. Semiconducting nanowires (made of metal sulfide and rare-earth phosphate nanostructures) are being used as components for several nanoscale energy-conversion, photonic, and electro-optical devices. There are challenges associated with achieving a controlled synthesis of semiconducting nanowir...

Novel Polymeric Prosthetic Heart Valve Technology for Transcatheter Aortic Valve Replacement

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 11:40:32 GMT

A novel valve design with uniquely optimized durability and hemodynamic performance Background: Heart valve related diseases remain a significant public health issue affecting an estimated 2% of the population with 4% of those over 65 having aortic stenosis (a narrowing of the valve opening leading to heart failure), the most common and life threatening form of heart valve disease. About 33% of people in need of valve replacement are considered inoperable. The current standard of care relies upon open-heart surgery to replace diseased valves with either mechanical or bioprosthetic va...

Noninvasive Epithelial Cancer Diagnosis and Grading

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 11:31:45 GMT

A novel OCT system to acquire high resolution, in-depth optical images of living tissue samples. Background: Optical Coherence Tomography (OCT) works by projecting a laser into tissue. When the light is reflected back, the OCT microscope uses an optical interferometer to detect a proportion of the light that is least back scattered. The system discards the multiple scattered light and uses depth-resolved and intensity information to generate an image. Unfortunately, most biological tissue, such as urinary bladder tissue, is optically opaque. Not only does it absorb the light but scatt...

Identifying and Quantifying Tumor Infiltrating Lymphocytes in Standard Pathology Images Using AI

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 11:28:23 GMT

This AI-derived TIL mapping provides a reproducible and robust tool for the assessment of lymphocytic infiltrates Background: Human review of diagnostic tissue is qualitative, and is therefore prone to high amounts of inter- and intra‑observer variability. Digital pathology, or the review of digitized pathology slides is gaining traction, precisely because quantitative measurements on digitized whole slide images, leads to reproducible and significant nuances observations. The recent approval of whole slide imaging for primary diagnostic uses is leading to widespread adoption of digital whol...

Selective Metallic Tube Reactivity in the Solution-Phase Osmylation of Single-Walled Carbon Nanotubes

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 11:23:27 GMT

Method of differentiating metallic carbon nanotubes from semiconducting carbon nanotubes Background: Since their discovery in the early 1990s, carbon nanotubes have been the focus of intense study due to their very desirable and unique combination of physical properties. They are chemically inert, thermally stable, highly strong, lightweight, flexible and electrically conductive. In fact, carbon nanotubes may potentially be stiffer and stronger than any other known material. Noncovalent and covalent sidewall chemistry to probe differential reactivity in metallic and semiconducting nanotubes ...

Rational Sidewall Functionalization, Functional Group Distribution and Purification of Nanotubes by Ozonolysis

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 11:03:37 GMT

Method of functionalizing the sidewalls of a plurality of carbon nanotubes with oxygen moieties Background: Carbon nanotubes are currently being proposed for numerous applications, such as, for example, catalyst supports in heterogeneous catalysis, high strength engineering fibers, sensory devices and molecular wires for the next generation of electronics devices. However, the current methods for purifying carbon nanotubes involve unreliable, low-yield processes. Also, current methods for adding oxygen moieties to carbon nanotubes are unpredictable with respect to the location of the moietie...

Novel Functionalization and Solubilization Methodologies for Carbon Nanotubes

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 10:58:03 GMT

Methods of making soluble carbon nanotube adducts that result in high levels of nanotube solubility in a variety of organic solvents Background: A carbon nanotube is a single graphene sheet in the form of a seamless cylinder. The ends of a nanotube typically have hemispherical caps. The typical diameter of a nanotube ranges from about 1nm to 10nm. The length of a nanotube potentially can be millions of times greater than its diameter. Since their discovery in the early 1990s, carbon nanotubes have been the focus of intense study due to their very desirable and unique combination of physical ...

Novel Bioabsorbable Membranes for Cell Delivery Applications

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 10:55:47 GMT

Methods for storing viable cells and for delivering viable cells to a mammal using the cell storage and delivery system. Background: Methods and compositions for encapsulating core materials, e.g., materials containing drugs, have been disclosed. These methods generally involve encapsulating the core material within a micro capsule by forming a semipermeable membrane around the core material. Although a number of processes for micro encapsulation of core material have been developed, most of these processes cannot be used for pH, temperature or ionic strength-sensitive material...

Reconfigurable Wireless Data Center Network Using Free-Space Optics

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 10:40:33 GMT

System and method for developing low cost and low maintenance data center networks Background: Data centers are a critical piece of today's networked applications in both private and public sectors. The key factors that have driven this trend are economies of scale, reduced management costs,better utilization of hardware via statistical multiplexing, and the ability to elastically scale applications in response to changing workload patterns. A robust data center network fabric is fundamental to the success of data centers and to ensure that the network does not become a bottleneck for high-p...

GPU-assisted Fast Medical Image Reconstruction

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 10:23:34 GMT

Data collection and processing for ultra-fast medical image reconstruction. Background: The advent of medical imaging of the anatomy's structure and function has allowed radiologists to view a patient's anatomy without the immediate need for invasive surgery. Transmission Tomography (TT), such as Computed Tomography (CT), allows the radiologist to view the patient's anatomical structure, while Emission Tomography (ET) allows the radiologist to view the patient's anatomical function. Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) are common technique...

Compound Semiconductor Device on Virtual Substrate

linda.galvin@stonybrook.edu — Sun, 05 Jul 2020 10:16:19 GMT

Fabrication of infrared photo detectors with high quality and appropriate thicknesses. Background: The detectors for semi conductors must 1) have a low defect density 2) have complete control over alloy composition of the materials grown. However, traditional infrared photodetectors are created by elements in Group III or V of the periodic table, must fit qualities that will not hinder the capabilities of the semiconductor itself. An example of this problem is radio communication. If the material used to create the photodetector has too much lattice energy, the band gap (eV) able to be detec...

Microfluidic Device for True Single-Cell Encapsulation

linda.galvin@stonybrook.edu — Wed, 01 Jul 2020 08:19:42 GMT

A device able to perform true single-cell encapsulation in droplets of arbitrary sizes, independent of the cell size Background: Technologies based on droplet microfluidics have facilitated single-cell analysis, paving the way to dissect the role of tissue heterogeneity in diseases such as cancer. Droplet platforms usually operate at very high-throughput but are unable to reliably deposit single cells in droplets of any given sizes, which hinders the development of devices for processing precious samples of limited availability such as needle biopsies or isolated CT. Technology Overview: ...

Method and Apparatus for Obvious Transaction Processing

linda.galvin@stonybrook.edu — Wed, 01 Jul 2020 08:17:58 GMT

New paradigm for outsourcing the transaction processing back-end of a multi-client database application to an un-trusted service provider Background: Increasingly, data management is outsourced to third parties. This trend is driven by growth and advances in cheap, high-speed communication infrastructures as well as by the fact that the total cost of data management is 5-10 times higher than the initial acquisition costs. Outsourcing has the potential to minimize client-side management overheads and benefit from a service provider?s global expertise consolidation and bulk pricing. Providers ...

Nanocomposite Fibers and Films Containing Polyolefin and Surface-Modified Carbon Nanofibers

linda.galvin@stonybrook.edu — Wed, 01 Jul 2020 08:15:10 GMT

Modifying carbon nanotubes with organic compounds to produce both fibers and films having enhanced mechanical and electrical properties Background: Carbon nanotubes, including single-wall nanotube (SWNT), multi-wall nanotube (MWNT) and carbon nanofibers (CNFs), have recently received a great deal of attention in the polymer community. Efforts have been undertaken to develop super-tough composite materials based on carbon nanotubes and polymer matrices. For example, one study has demonstrated the super-tough performance of polyvinyl alcohol (PVA)/single wall carbon nanotube (SWNT) nanocomposi...

Virtual Prostate Visualization & Computer-Aided Detection

linda.galvin@stonybrook.edu — Wed, 01 Jul 2020 08:12:40 GMT

Method, system, and computer-readable medium for detecting a disease of a prostate Background: Prostate cancer (CaP) is the most commonly diagnosed cancer among males in Europe, and is the second leading cause of cancer related mortality for this same group. Although it is such a common cancer, diagnosis methods remain primitive and inexact. Detection relies primarily on the use of a simple blood test to check the level of prostate specific antigen (PSA) and on the digital rectal examination (DRE). If an elevated PSA level is found, or if a physical abnormality is felt by the physician durin...

Scanning Confocal Acoustic Diagnostic for Bone Quality

linda.galvin@stonybrook.edu — Wed, 01 Jul 2020 08:08:31 GMT

A system for determining at least one bone property of a bone sample Background: This invention deals generally with the diagnostic methods and apparatus for determining the quality and condition of bones and sample materials. The methodology supporting this technology is for determining invasively, destructively the condition of certain bones in humans and animals. Technology Overview: The system includes transmitting ultrasonic transducer and a receiving ultrasonic transducer, both of are confocal transducers. The transducers are configured to receive the material sample between the conf...

Disk-Resident Streaming Dictionary

linda.galvin@stonybrook.edu — Tue, 30 Jun 2020 09:25:40 GMT

Computer program product for storing data in a disk storage system utilizing efficient and optimal insertion speed. Background: Modern networks utilize and generate high‑bandwidth streams of data, often creating the issue of data being produced at a faster rate, as compared to the ability of data being inserted into a database. Many industries face the data stream issue, as it is easier to collect data at a high rate, but they are not necessarily able to have indexing and searching of this data at an efficient rate. Almost all database or file systems employ a data dictionary mapping ke...

Collision Resolution Protocol for Mobile RFID Tag Identification

linda.galvin@stonybrook.edu — Tue, 30 Jun 2020 09:22:58 GMT

Performance of a radio frequency identification (RFID) system is improved by a protocol that eliminates collisions between signals. Background: Radio frequency identification (RFID) is a method to retrieve and store data using a radio channel. The system consists of tags and a reader. This tag is essentially a radio frequency circuit, a CPU, and a small memory with a unique identifier. Wireless connectivity allows for communicating and giving the system ability for tracking and managing objects in real time. RFID systems face the challenge of tag collision. Where one channel is being used be...

Large-Area PIN Diode with Reduced Capacitance

linda.galvin@stonybrook.edu — Tue, 30 Jun 2020 09:17:00 GMT

Novel design of PIN diode that simultaneously has a low capacitance and a large area of effective collection of photo-generated charge Background: It is highly desirable to implement a PIN diode that collects light from the same area but has a substantially lower capacitance, so that the sensitivity threshold can be greatly improved. The diode capacitance is a key parameter that governs the noise in the front-end amplifier circuit, which is mainly associated with the thermal and flicker noise of the input transistor. The input transistor dominates the noise introduced by readout electronics ...

A Coherent Imaging Fiber Based Hair Removal Device

linda.galvin@stonybrook.edu — Tue, 30 Jun 2020 08:17:45 GMT

Low power, portable hair removal device utilizing coherent imaging fiber technology. Background: Laser and other optical techniques for hair removal are based on non selective thermal damage of the hair shaft and/or hair follicle by absorption of optical energy. Existing commercially available systems flood a large area of hair populated skin with the anticipation that some percentage of the incident energy will be absorbed by the hair shaft, thereby resulting in hair depilation. As a result, the surrounding tissue temperature increases significantly requiring external cooling and/or control...

In-situ Quantum Dot Growth on Carbon Nanotubes

linda.galvin@stonybrook.edu — Tue, 30 Jun 2020 08:14:01 GMT

Carbon nanotube technology with precise control of optical and electronic properties of the resulting device. Background: There are significant shortcomings of current methods by which to modify the physical properties of nanotubes. For example, there has been poor control over the surface coverage and degree of clustering of nanocrystals on nanotubes. The surface coverage and clustering directly affect the physical properties of the resulting nanotube. Thus, current methods do not allow for precise control of the physical properties of nanotubes. Current methods of producing heterostructure...

Apparatus and Method for Optimal Phase Balancing Using Dynamic Programming with Spatial Consideration

linda.galvin@stonybrook.edu — Tue, 30 Jun 2020 08:12:20 GMT

Phase balancing algorithm for manual or automatic tap changing. Background: The majority of electric power systems utilize, in the electric distribution system, feeders which carry three phases of alternating current/voltage. It is desirable for electric utilities and providers of electric power distribution systems to have approximately equal loads on each phase. This is a problem as even if loads are initially balanced, with time loads increase, decrease, are added, or are removed from each phase, which causes an imbalance of loads. Even during the same day there may be much variation of l...

Automated Patient Code Recognition Software

linda.galvin@stonybrook.edu — Tue, 30 Jun 2020 08:07:17 GMT

A software program which tracks admitted patients and pushes charted data to physicians, enabling the identification of co-morbidities. Background: Co-morbidities affect patients healing, survival, and length of hospitalization. Knowledge and documentation of co-morbidities is important information for a patient's health team. Proper documentation of comorbidities is important for hospital coding in analyzing service intensity weight. This project seeks to provide an automated search of the electronic health record and pull co-morbidities from laboratory values, vital signs monitoring, radio...

General, Room-Temperature Method for the Synthesis of Isolated as well as Arrays of Single-Crystalline ABO4-Type Nanoroda (BNL 15-22)

linda.galvin@stonybrook.edu — Tue, 30 Jun 2020 07:47:27 GMT

Pure single-crystalline metal oxide and metal fluoride nano structures. Nano structures include nanorods and nano-arrays. Background: Metal oxides and metal fluorides are important in the aspect of their structure‑related properties, including superconductivity, ferroelectricity, magnetisms and conductivity. Prior art methods of synthesizing fluoride nano-structures are by hydrothermal and or solvothermal methodological approaches, which have substantial shortcomings. These methods do not allow for the synthesis of pure single‑crystalline nano-structures with predictable size and morph...

Hydrothermal Synthesis of Perovskite Nanotubes

linda.galvin@stonybrook.edu — Tue, 30 Jun 2020 07:45:48 GMT

A monophasic perovskite nanotube, characterized by means of X-ray diffraction and transmission electron microscopy. Background: Behavior of ferroelectric materials at the nanoscale dimension is of importance to the development of molecular electronics, in particular for random access memory (RAM) and logic circuitry. Transition metal oxides with a perovskite structure are noteworthy for their advantageous dielectric, piezoelectric, electrostrictive, pyroelectric and electro‑optic properties. Technology Overview: Monophasic essentially denotes a perovskite nanotube ...

Multi-tier Caching for High-throughput Indexing Source Code

linda.galvin@stonybrook.edu — Tue, 30 Jun 2020 07:44:31 GMT

A method for maintaining an index in multi-tier data structure. Invention utilizes key-value storage, and index caching using key-value pairs. Background: Index machines comprise of a cluster or surplus of databases and or file systems. The volume of index data being generated by network connected devices is outpacing data storage technologies’ speed, capacity and abilities. Applications that create index data and generate large volumes of index data. Data deduplication systems is technology made in efforts of carrying out the elimination of redundant data. Success...

Multi-Cell Multi-Layer High Voltage and Cost Effective Supercapacitor

linda.galvin@stonybrook.edu — Tue, 30 Jun 2020 06:42:32 GMT

A novel supercapacitor apparatus that improves on current individual supercapacitor units Background: Supercapacitors are promising energy storage devices. Due to their fast charge‑discharge characteristics, low resistance, long cycle life, and wide operating temperatures, supercapacitors are used in industries such as transportation, grid energy storage, and industrial applications; there is a rapidly growing demand for these storage systems. However, individual supercapacitors have low stand‑off power (< 3 volts) and energy densities. In order to hold a higher voltage (+10 volts) th...

Novel Drugs for the Treatment of Tuberculosis

linda.galvin@stonybrook.edu — Tue, 30 Jun 2020 05:31:59 GMT

Compounds that increase TB therapy efficacy through a mechanism of action for increased tolerance and decreased therapy duration. Background: One third of the world's population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. The current recommended treatment regimen for TB begins with a two-month intensive therapy using isoniazid, rifampicin, pyrazinamide, and ethambutol followed by four months of treatment with isoniazid and rifampicin. The long and complex treatment regimen leads to high levels of nonadherence. This contributes to the development of ...

MyBody MyPlan: Connecting The Right People to the Right Information and to Each Other

linda.galvin@stonybrook.edu — Fri, 31 Jan 2020 08:02:55 GMT

An app built around the patient and the many stakeholders the patient encounters as he/she navigates life and the medical system Background: 70% of health care dollars in the U.S. are spent on the treatment of chronic diseases. MyBody MyPlan bridges an information gap that poses an obstacle to successful chronic disease management for many individuals whose health depends upon their ability to successfully execute a self-management plan (SMP). The array of stakeholders (medical and non-medical) involved in the care of a single patient often lack common knowledge of key aspects of an individu...

Measuring Blood Brain Barrier Dysfunction

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:27:40 GMT

An MRI based approach to map blood brain barrier permeability in human subjects Background: Blood-brain barrier (BBB) disruption may be the key mechanism leading to neuronal dysfunction in neurological and psychiatric disorders including multiple sclerosis (MS), Parkinson's (PD), Alzheimer's (AD), bipolar, autism, schizophrenia and epilepsy. Existing approaches to measure BBB integrity often involves toxic exogenous contrast agents and requires ionizing radiation. Their sensitivity is very limited to detect the subtle BBB disruption in most psychiatric diseases. Therefore, a capability of no...

Novel Monoclonal Antibodies to Treat Carbapenem-Resistant Klebsiella Pneumoniae Infections

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:26:56 GMT

These mABs elicit phagocytic activity and protective immune response to clear bacteria from infected mice. Background: Carbapenem-resistant K.pneumonia (CR-Kp) strains are a major threat worldwide due to the difficult to treat. Lack of new antibiotics in pipeline and the emergence of resistance to the last-resource antibiotics has resulted in an urgent need to develop novel treatment strategy. Such a treatment strategy would ideally be:1. not susceptible to resistance development and,2. specific to pathogenic organism without affecting microbiome. Technology Overview: Researchers at Stony Br...

Point of Care Gout Detection Device

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:26:51 GMT

A colorimetry based bedside gout detection device that can also distinguish gout from pseudogout. Background: Gout, a prevalent and often debilitating disease, is characterized by the painful deposition of uric acid crystals in synovial fluid. The gold standard of gout diagnosis is detection of crystals in synovial fluid through polarized light microscopy; however, this procedure is time-consuming, costly, and requires trained technicians. Investigators at Stony Brook University have developed a method and device to detect gout bedside, which will (a) considerably reduce diagnostic costs; (b...

Air-Powered Centrifuge

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:26:43 GMT

A light weight, low-cost and easily transportable centrifuge that does not require electric power to operate. Background: Centrifugation is a common technique generally used in the laboratory or in the field to separate biological samples, such as blood. Standard benchtop mini-centrifuges are powered by an electrical outlet and are heavy, in part, because of the metallic components of the electrical motor. Mini centrifuges are also expensive to produce due to the multiple components required to secure a heavy spinning rotor and the necessity of a correspondingly heavy shield to protect user...

Novel Inhibitors of Matrix Metalloproteinase-9 for Anti-Cancer Drug Development

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:26:42 GMT

Inhibitors that target a site on MMP-9's hemopexin domain that are distinct and cannot be functionally substituted for one another. Background: Matrix Metalloproteinase-9 (MMP-9), a type IV collagenase, is linked to cancer progression and metastasis. Despite increased evidence of correlation between MMP-9 and tumor metastasis, no success has been achieved in exploiting MMP-9 as a drug target, predominantly due to the conserved nature of target site. The target site traditionally exploited in MMP-9, is its catalytic domain, which is known to be highly conserved across several MMPs and th...

Rapid Trace Biomarker Detection Device

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:26:27 GMT

A device that enables detection of biomarkers present in trace amounts in urine. Background: A variety of biomarkers are known to be secreted in urine however due to (a) their secretion in trace amounts and (b) technical limitations of existing detection methods, exploitation of urine biomarkers in diagnosis and prognosis is limited only to a handful number of indications. Furthermore, most in-development devices focus on using minimal sample volume and typically rely on sophisticated electronic and optical techniques for higher sensitivity. To overcome the current roadblocks t...

Antiviral Compounds with a Unique Mechanism of Action

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:26:17 GMT

Host-directed viral inhibitors that target a highly conserved cellular machinery necessary for the viral life cycle. Background: HIV is a major global public health problem that lacks a cure, however available anti retrovirals have been successful in improving and extending the quality of life in patients. This success has recently encountered a set-back due to emergence of drug resistant variants of HIV. Therefore, increasing incidence and emerging resistance has resulted in a need to develop novel therapeutic intervention against these enveloped viruses. Technology Overview: Researchers ...

A Novel PET Imaging Agent for Diagnosing Bacterial Infections

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:26:12 GMT

A PET tracer, [18F]F-PABA which is taken up only by bacterial cells thus making it specific for diagnosing infection. Background: Bacterial infections such as those of prosthetic joints, bones (osteomyelitis) and heart valves (infective endocarditis) are difficult to diagnose and treat, and are a major cause of mortality, morbidity and health care costs. PET is a promising, non-invasive imaging technique for detecting and localizing infections in humans. Most of the current PET studies rely on FDG, however, this tracer lacks specificity since it can be taken up by host inflammatory cells as ...

Neonatal Thoracotomy/ Thoracostomy Skills Trainer

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:26:03 GMT

A cost effective and anatomically realistic model for neonatal chest tube insertion and pericardiocentesis. Background: Chest tube insertion is a vital life saving procedure in many neonates. If performed incorrectly, the procedure could result in serious complications such as hemorrhage, perforation of lung and other serious internal injuries. Despite being critical and technically challenging, many practitioners do not receive adequate training due to unavailability of an affordable anatomically realistic model for chest tube insertion. Technology Overview: Inventors at Stony Brook Univ...

High-Throughput 3-D Invasion Assay

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:25:46 GMT

A novel invasion plate design and methods which enables increased throughput, standardization and quantification of cell invasion. Background: The ability of cancer cells to invade into surrounding matrices is a critical determinant of metastasis and failure to prevent metastasis has reinforced the unmet need of targeting cancer invasion. To expedite the overall drug screening process, considerable efforts have been focused on development of practical 3D cell culture platforms for drug discovery. However, current 3D cell-based assays have not yet been incorporated into drug development progra...

Novel Purine Nucleotide Analogs

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:25:31 GMT

The analogs demonstrate increased mismatch discrimination making them a useful tool for or creation of various DNA hybridization methods. Background: A number of artificial oligonucleotides have been developed that stabilize duplexes by maximizing stacking interaction, by forming additional hydrogen bonds, or by minimizing electrostatic repulsion between DNA strands. The phenoxazine dC analogue or ?G-clamp? utilizing these effects was developed that is capable of bringing to complementary guanine with high affinity and specificity. Unfortunately, the nucleotides with comparable affinity towa...

BRIKARD: Builder of Recursive Inverse Kinematic Assembly and Ring Design

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:24:44 GMT

Predicting conformations of artificial macrocycles and their interaction with target proteins. Background: Macrocycles (MCs) are an extremely promising class of new drugs with a broad range of therapeutic applications. The challenge is they are hard to design using conventional “wet” combinatorial methods which makes in silico approaches especially important for design of MCs. Design of new drugs tailored to specific targets requires combining conformational sampling with combinatorial design and docking algorithms. Existing algorithms developed for small molecules pe...

Fluoroscopic Device Guide - Devices, Systems and Methods For Placement of Instruments For Medical Procedures - Modifications

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:23:57 GMT

Fluoroscopic guided system procedure for the passage of needles towards a deep target in the body with less x-ray exposure and improved accuracy. Background: Fluoroscopic guided procedure require passage of needles or other devices towards deep target in the body that cannot be seen with plain vision. Fluoroscopy allows the visualization of deep structures but in typical practice the needle or other device is passed freely through the tissue by the operator requiring adjustments to trajectory once the needle has already been inserted into the patient. Technology Overview: Dr. Christopher P...

Bi Directional Dual-Color Light Emitting Devices

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:23:12 GMT

A technology that permits the generation of two wavelengths of light from a single LED where either wavelength can be active at any time. Background: Light emitting diodes (LEDs) are semiconductor devices that convert electrical energy into light. Like all diodes, they conduct electricity differently in one direction as compared to the other. A typical LED conducts easily in the ?forward? direction (emitting light), while blocking current in the ?reverse? direction. Stony Brook University is developing superlattice LEDs, which differ from typical LEDs in that they conduct current well in bot...

Triazine-Based Tripod Linker System for Drug Delivery and Diagnosis

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:23:10 GMT

This tumor-targeted drug delivery system uses biotin as a tumor targeting moiety and taxoid-camptothecin combination. Background: Combination therapy is the primary treatment option against cancer, because multiple agents in combination, synergistically improve efficacy and are less prone to resistance due to their distinct action mechanisms. Despite these advantages, lack of tumor specificity continues to be a serious issue in combination therapy, thus resulting in a need to develop an efficient vehicle for targeted drug delivery. Technology Overview: Researchers at Stony Brook Universi...

Asymmetric Bow-Tie Dendrimers as Versatile Platform for Drug Delivery and Diagnosis

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:22:37 GMT

Novel multifunctional asymmetric bow-tie dendrimers as a robust platform for drug delivery systems and diagnostic agents. Background: Dendrimers are nano-sized globular macromolecules that have been well studied as a drug delivery vehicles. Their convenient synthesis strategy, easy functionalization of the terminal end group and versatility in designing, make dendrimers such as PAMAM, a choice for drug carrier. Additionally dendrimers as macromolecular carrier have large loading capacity to achieve high concentration at tumor sites. Therefore a controlled strategy to functionalize dendrimers...

Single Chain Antibody (Mab69) Against the NG2 Proteoglycan

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:22:29 GMT

AAV based viral vectors that express either AAV-NG2Ab or AAV-NT3 have been shown to provide improved recovery of motor function in models. Background: Spinal Cord Injury (SCI) affects nearly 270,000 Americans and is a common cause of permanent disability and death in children and adults. Despite being a significant burden to the patients, society and healthcare industry, SCI currently has no treatment. It is known that, upon SCI, macrophages/ microglial cells rush to the site and contribute in development of inflammatory response at the injury epicenter. Therefore manipulating these first re...

A Novel Clinical Decision Support System for Analysis of Fetal Heart Rate and Maternal Uterine Pressure Signals Based on Generative Models

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:22:12 GMT

An obstetrician has a reliable decision support system that will benefit the fetus, the mother, and the obstetrician Background: Electronic fetal monitoring (EFM) involves simultaneous monitoring of the fetal heart rate (FHR) as well as the maternal uterine pressure (UP) signal. In practice, EFM has been based on visual analysis of FHR patterns and thereby is rather subjective. A reliable computer-based system for accurate and meaningful classification of FHR signals does not exist on the market. The obstetric practice needs a system to fill the void. Technology Overview: Presented is a sy...

Sensors for Power Distribution Network

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:22:10 GMT

Monitoring the state of a power distribution network so that control rooms can be alerted to changes before the point of complete shut down Background: A significant shortcoming to power grid distribution systems is the lack of status. Systems do not know their own state nor the quality of their state. This is understood in times of failure such as power outages. Making power distributions rapidly recoverable after incidents such as natural disasters, is perhaps the most urgent task in on‑going improvement of infrastructure. Present monitoring state of power grids is complete shu...

Rainbow Infant Incubator

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:22:02 GMT

Light weight, foldable infant incubator that requires minimal space for storage and is easily assembled in minutes. Background: Current incubators are large, heavy and expensive. Storage of any more than a few of these units is not practical due to space restrictions. In addition, the current incubators are difficult to transport from one location to another (requiring a truck with a lift gate) in the event of a natural or manmade disaster. Technology Overview: Dr. Craig Lehmann, Professor at Stony Brook University invented the Rainbow Infant Incubator which is light weight (under 25 poun...

Physician Attribution Software (PAS): Determining Physician Attribution Related to In-Patient Care Using Prediction-Based Analysis

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:21:21 GMT

A computational model that uses patient's EHR data to achieve 97% accuracy in physician attribution. Background: Lack of effective tools that measure Physicians performance presents a major obstacle in improving quality and health care cost in the US. Existing approaches are either not geared towards in-patient visits or rely on expensive tools that are claims-based and are entirely dependent on accurate/ timely billing. Therefore, an effective tool that identifies, measures and evaluates physicians performance is necessary to drive various healthcare agencies initiative ...

Intralipid as a Contrast Agent to Enhance Subsurface Blood Flow Imaging

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 11:21:16 GMT

Novel 3D neuroimaging technique to investigate functional changes in the small neurovascular network Background: Conventional techniques (for example, MRI and CT angiography) fail to provide sufficient spatiotemporal resolutions to measure rapid cerebral blood flow changes in small vessels which restricts its use for assessing cerebrovascular networks, and may not be suitable for repeated imaging of disease progression. Technology Overview: Dr. Yingtian Pan, Professor at Stony Brook University created a novel 3D neuro-imaging technique to investigate functional changes in the small neurova...

Next-Generation Taxoids

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 10:31:01 GMT

Novel fluorine-containing taxoids with high potency against drug-resistant cancer. Background: Paclitaxel and docetaxel have been extensively used in clinic for treatment of various cancers. However, their lack of tumor-specificity frequently results in an assortment of undesired side effects and exhibit little efficacy in treating melanoma, pancreatic, gastric, brain and renal cancers. These limitations are, at least in part, due to multi drug resistance (MDR) caused by over expression of ABC cassette efflux pumps and the beta III tubulin isoform. Technology Overview: Stony Brook Uni...

Biliverdin IXβ Reductase

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 10:29:46 GMT

Developing first-in-class therapy for patients with thrombocytopenia. Background: Thrombocytopenia is a medical condition characterized by low platelet counts. Thrombocytopenia can be brought on as a result of a separate disorder such as leukemia, an immune system problem or it can be an adverse result of taking medication, such as chemotherapy. Symptoms can be mild to severe and could result in the need for medication, surgery or life-long blood transfusions. Many of the treatments prescribed for thrombocytopenia have side-effects, including becoming refractory to platelet infusions, st...

Novel Spinal Cord and Epidural Blood Flow & Oxygenation Monitoring Device

linda.galvin@stonybrook.edu — Fri, 24 Jan 2020 10:12:04 GMT

A fiber optic device that allows for the immediate detection of changes in spinal cord blood flow and oxygenation Background: Spine trauma, as a result of motor vehicle accidents, falls, violence, and sports activities, is a global problem. Rates vary from 12-60 cases/million, with annual costs in the United States approaching $10,000,000,000/yr. In addition to this, many patients, adult and pediatric, suffer neurological injury secondary to vascular procedures, resection of spinal cord tumors, and as a result of attempts at the correction of acquired spine deformit...

Novel Soluble Amylin Formulations for Co-injection with Insulin

linda.galvin@stonybrook.edu — Thu, 19 Dec 2019 08:31:59 GMT

Amylin variants which are much more soluble than the wild type peptide, designed to be co-formulated with insulin to treat diabetes. Background: Administration of Islet Amyloid Polypeptide IAPP with Insulin (as a separate injection) helps to normalize fluctuating glucose levels to a greater degree than is possible with insulin alone. Unfortunately, human IAPP is extremely amyloidogenic and prone to aggregate, preventing its direct use as an adjunct to insulin therapy. The poor solubility of IAPP drastically increases the cost of IAPP as a therapeutic and limits its effectiveness, (the diffi...

Immersive Gigapixel Display

linda.galvin@stonybrook.edu — Thu, 19 Dec 2019 08:31:44 GMT

World's first immersive gigapixel resolution display, offering more than 1.5 billion pixels Background: Need to break barriers in data visualization and help professionals deal with the challenges presented by the massive datasets of today and tomorrow. Technology Overview: Dr. Arie Kaufman, Distinguished Professor and Chair of the Computer Science Department at Stony Brook University created the world's first immersive gigapixel resolution display, offering more than 1.5 billion pixels, multiple times the resolution of other tiled display systems. The Reality Deck is built and is located ...

Electricity-Generating Shock Absorbers

linda.galvin@stonybrook.edu — Thu, 19 Dec 2019 08:31:24 GMT

A regenerative shock absorber system with a high energy density that recovers the vibration energy of a vehicle that is otherwise lost Background: Among all sources of pollutants, the transportation industry has a largely significant contribution. Although innovations such as hybrid engines have made fuel consumption more efficient, the uses of renewable energies are still being explored. The use of recycled energy comes into play. Kinetic energy during a vehicle's motion can be stored and used to recycle power to the engine. Technology Overview: Stony Brook University Department of Mechan...

High Flux and Low Fouling Nanofibrous Ultrafiltration Membranes

linda.galvin@stonybrook.edu — Thu, 19 Dec 2019 08:27:15 GMT

A membrane suitable for ultrafiltration, microfiltration, and nanofiltration that's less expensive and more efficient Background: Ultrafiltration (UF) is a method for separating dissolved molecules in a solution; it's used for water purification. Current UF technology employs ceramic micro-filters; the problems with these include high fouling rates and high costs. These problems result from characteristics such as the membrane surface, surface-to-volume ratio, flow rate, etc. Polymeric membranes are being studied as a replacement; they are commercially available, but currently have di...

Benzimidazoles and Pharmaceutical Compositions Thereof

linda.galvin@stonybrook.edu — Tue, 17 Dec 2019 13:06:53 GMT

A novel cell division inhibitor with efficacy against Mycobacterium tuberculosis Background: Multidrug-resistant tuberculosis (MDR-TB) and extensively drug resistant TB (XDR-TB) are a significant public health threat for TB control efforts. Despite efforts in last 50 years, development of new TB treatments have been limited to drug targets like cell wall biosynthesis, ATP synthesis, RNA synthesis, leading to resistance in these areas. Hence, there is a need to discover novel drugs that target other bacterial processes in order to counter the developed bacterial resistance. Tec...

Genetically Engineered AAV Rep for Gene Targeting and rAAV Production

linda.galvin@stonybrook.edu — Thu, 07 Jun 2012 13:22:28 GMT

Researchers at Stony Brook University have identified a genetic element within the Rep gene sequence which is inhibitory to Ad replication. Background: Gene therapy strategies have exploited lenti or retro viral approaches for long-term gene replacement, however, their clinical applications remain limited because of potential for viral-associated oncogenesis. Recently, gene therapy strategies have attempted to use hybrid Adenovirus/Adeno-associated viruses (Ad/AAV) to combine the capacity, tropism and ease of production of adenovirus (Ad) with adeno-associated virus (AAVs) ability...

Magnetic Graphene Oxide and Graphene Nanoribbon Nanoparticles

linda.galvin@stonybrook.edu — Thu, 07 Jun 2012 07:14:53 GMT

A nanoparticle based MRI CA consisting of graphene nanoparticles intercalated and coordinated with trace amounts of manganese. Background: MRI contrast agents are routinely employed during MRI examinations to improve diagnostic confidence. Gadolinium (Gd)-based MRI-CAs dominate the market and are considered the “gold standard.” However, in patients with advanced renal failure, some of of these Gd-based CAs have induced a disease known as nephrogenic systemic fibrosis (NSF); a rare but severely debilitating condition that hardens and thickens the skin that results in joint co...

Inhibition of the Soluble Extracellular Domain of E-cadherin: A Novel Tumoricidal Drug for Cancers

linda.galvin@stonybrook.edu — Thu, 07 Jun 2012 07:13:43 GMT

Monoclonal antibodies that have demonstrated profound antitumor effects both in vitro and in vivo. Background: Over the last decade, the most significant revolutionary advances in oncology have been the introduction and FDA approval of targeted monoclonal antibodies (mAb) against the human epidermal growth factor receptor (HER1-4) family. In combination with standard adjuvant chemotherapy, drugs such as Cetuximab (Erbituxa®, HER1 inhibitor) or Trastuzumab (Herceptin®; HER2 inhibitor) have significantly increased disease-free survival in patients with metastatic breast and other epith...

Latest technologies from State University of New York at Stony Brook

Few Shot Visual Counting

Facile Synthetic Approach Toward Crystallite Size Control of Mixed Metal Phosphorous Oxide Battery Materials

Extended Life Rechargeable Battery or Capacitor

Real-time APT Detection through Correlation of Suspicious Information Flows

Chemical Strategies for Improving Performance of Electrode Materials for Batteries

Nestin-GFP transgenic reporter mouse line

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Monolithic Retroreflector Based Detector for PET Imaging

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Method for Sampling Terahertz Pulses in the Time-Domain Using Modulated Difference-Frequency in the Repetition Rates of Femtosecond Lasers

Sterylglucosidase Inhibitors as Antifungal Agents

Enzyme replacement therapy in Niemann-Pik Disease

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Small Molecules for Cancer Therapy that Reduce the Expression of Transcription Factors KLF5 and EGR-1

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Compact Optical-EEG for Recovery Prediction in the ICU

Zinc sulfur batteries catalyzed by dichalcogenides

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Non-invasive, In Vivo Enhancement of Immune Function and Immunotherapy by use of Low Intensity Vibration

3D CT Reconstruction from Few X-rays

A Novel Method to Assist the Orthopedic Surgeon in Bone Fracture Surgery

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MotionGen

Decellularized Engineered Vascularized Skin Architecture (DEVA™)

An anti-capsular antibody that cross protects against clade 1 Carbapenem-resistant Klebsiella pneumoniae

Artificial Polymeric Valves System and Methods of Making and Using Thereof

SeeMe: A novel tool for measuring and detecting human consciousness

A Point-of-care Ultrasonography Simulation System for Educational Use in Non-Stationary Medical Environments

Acceleration of Human T Cell Expansion In Vitro Using Low Intensity Vibrations to Improve Biomanufacturing Process

Sts-/- mice

A Closed-Loop Stimulation Controller for Exploring Neural States

LpxC Inhibitors for Gram-Negative Infections

Design and Synthesis of Novel Methotrexate Conjugated MicroRNA Mimic Modified with 5-Fluorouracil and/or Gemcitabine as a Platform Technology for Cancer Treatment

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6-azasteroids with unique activity in mycobacteria

Novel Steel Composite for Nuclear Shielding

Metal-mediated, Autolytic Amide Bond Cleavage for the Selective, Metal-Complexation Catalyzed, Controlled Release of Metallodrugs

Reactive Phase Sintering of Oxide Dispersion Strengthened Nanocrystalline Alloys

Laser Assisted Ignition Method to Enable Ammonia Combustion

Flux Sweeper System

The Amine Functionalization of Nanocellulose and its Application for PFAS Removal as Adsorbent-based Coagulant

Modular Jig and Projector System to Align Cuts for Bone Repair Surgery

Method and System for Color Rendering in Augmented and Mixed Reality

GlanceWriter: Writing Text by Glancing Over Letters with Gaze

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App based customer support system for shopping markets

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