Novel Drugs for the Treatment of Tuberculosis

Background

One third of the world's population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. The current recommended treatment regimen for TB begins with a two-month intensive therapy using isoniazid, rifampicin, pyrazinamide, and ethambutol followed by four months of treatment with isoniazid and rifampicin. The long and complex treatment regimen leads to high levels of nonadherence. This contributes to the development of drug resistant TB that becomes more difficult and expensive to treat.

Technology

Researchers have identified novel compounds that are potentiators of existing TB drugs. These compounds work with both first-line and second-line TB drugs including those that are active against MDR-TB (e.g., Bedaquiline and PA-824). The drug scaffold from which these compounds were derived have high stability in vivo, low host toxicity, and excellent host bioavailability. The proposed therapy will reduce dose and/or time of treatment, and consequently reduce treatment costs and improve treatment outcomes.

Advantages

-Potentiator of both first-line and second-line TB drugs -Novel target and mechanism of action -Effective with both drug sensitive and drug resistant TB therapies -Leads are orally available with excellent PK

Application

- Tuberculosis - Anti-infective therapeutics

Patent Status

Patent application submitted

Stage Of Development

US 8,481,530 B2 PCT filed covering new compositions and methods of use

Licensing Potential

Development partner,Licensing,University spin out

Licensing Status

Additional Info

https://stonybrook.technologypublisher.com/files/sites/navpcy8qsm2lwlkqucaa_tb_in_sputum.png Please note, header image is purely illustrative. Source: CDC, Wikimedia Commons, public domain.

Category(s):

Campus > Stony Brook University

Technology Classifications > Drug Design and/or Synthesis

Case ID: R8775

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For Information, Contact:

Sean Boykevisch

Director

State University of New York at Stony Brook

6316326952

sean.boykevisch@stonybrook.edu

Inventors:

Nicole Sampson

Xinxin Yang

Tianao Yuan