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Design and Synthesis of Novel Methotrexate Conjugated MicroRNA Mimic Modified with 5-Fluorouracil and/or Gemcitabine as a Platform Technology for Cancer Treatment

A platform for modifying miRNAs and using the modified miRNAs as novel cancer therapeutics. RSS.HDBackground> Background: < Resistance to chemotherapy can be a highly complex issue, with epigenetic alterations playing a key role in tumorigenesis and chemotherapy resistance. The failure to treat several advanced solid tumors can be often attributed...

Published: 3/7/2025 | Inventor(s): Jingfang Ju, Iwao Ojima, John Yuen, Lei Chen

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Category(s): Technology Classifications > Therapeutics, Technology Classifications > Drug Design and/or Synthesis, Campus > Stony Brook University