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A Closed-Loop Stimulation Controller for Exploring Neural States

A brand-new type of reinforcement learning algorithm RSS.HDBackground> Background: < Current day algorithms governing how medical devices deliver stimulation to patients have not changed in well over 50 years and cannot account for neurological variabilities across individuals that come about from differences in genetics, lifestyle factors,...

Published: 2/4/2025 | Inventor(s): Ian Jordan, Il Park, Josue Nassar

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Category(s): Technology Classifications > Artificial Intelligence, Technology Classifications > Computer Software, Technology Classifications > Therapeutics, Technology Classifications > Medical Devices, Campus, Campus > Stony Brook University

Metal-mediated, Autolytic Amide Bond Cleavage for the Selective, Metal-Complexation Catalyzed, Controlled Release of Metallodrugs

Autolytic, metal complex-mediated amide bond cleavage for prodrug activation and synthesis of metallodrugs RSS.HDBackground> Background: < Clinically viable prodrugs release activated drug molecules at the site of interest, requiring close spatiotemporal control. Bond cleavage strategies for the release of the activated drug often incorporate...

Published: 2/4/2025 | Inventor(s): Eszter Boros, Dariusz Śmiłowicz

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Category(s): Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Drug Delivery, Campus, Campus > Stony Brook University

Positron Emission Tomography (PET) Radiotracer

Composition, method and diagnostic use of positron imaging tomography imaging agent for bacterial infection detectionRSS.HDBackground> Background: <Positron emission tomography (PET) radiotracer is a diagnostic tool to detect bacterial infection in humans. A deficiency exists in clinical diagnostic tools capable of identifying bacterial infections...

Published: 2/1/2024 | Inventor(s): Peter Tonge, Yong Li, Fereidoon Daryaee, Peter Smith-Jones, Labros Meimetis

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Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Imaging, Technology Classifications > Research Tools and Reagents, Campus, Campus > Stony Brook University

Antiviral Compounds with a Unique Mechanism of Action

Host-directed viral inhibitors that target a highly conserved cellular machinery necessary for the viral life cycle. Background: HIV is a major global public health problem that lacks a cure, however available anti retrovirals have been successful in improving and extending the quality of life in patients. This success has recently encountered a set-back...

Published: 2/28/2024 | Inventor(s): Carol Carter, Lorna Ehrlich

Keywords(s): Technologies

Category(s): Campus, Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Therapeutics