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Design and Synthesis of Novel Methotrexate Conjugated MicroRNA Mimic Modified with 5-Fluorouracil and/or Gemcitabine as a Platform Technology for Cancer Treatment
A platform for modifying miRNAs and using the modified miRNAs as novel cancer therapeutics. RSS.HDBackground> Background: < Resistance to chemotherapy can be a highly complex issue, with epigenetic alterations playing a key role in tumorigenesis and chemotherapy resistance. The failure to treat several advanced solid tumors can be often attributed...
Published: 3/7/2025
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Inventor(s):
Jingfang Ju
,
Iwao Ojima
,
John Yuen
,
Lei Chen
Keywords(s):
Category(s):
Technology Classifications > Therapeutics
,
Technology Classifications > Drug Design and/or Synthesis
,
Campus > Stony Brook University