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6-azasteroids with unique activity in mycobacteria

The compound functions as potentiators of several anti-tuberculosis drugs RSS.HDBackground> Background: < One third of the world’s population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. There are drugs to combat the bacteria by attacking the bacteria directly. The current recommended treatment...

Published: 5/14/2025 | Inventor(s): Nicole Sampson, Joshua Werman, Tianao Yuan

Keywords(s):

Category(s): Technology Classifications, Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis

Laser Assisted Ignition Method to Enable Ammonia Combustion

Overcoming carbon-free fuel challenges: laser-induced Ammonia combustion RSS.HDBackground> Background: < Decarbonization of the power production, transportation, industrial and building heating sectors is pivotal for meeting net-zero carbon goals of 2050. As solar and wind are rapidly brought online to decarbonize the power grid, we are faced...

Published: 8/29/2025 | Inventor(s): Dimitris Assanis, David Hwang

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Category(s): Technology Classifications, Technology Classifications > Clean Energy, Technology Classifications > Environment, Technology Classifications > Energy Conservation, Campus > Stony Brook University

Next-Generation Taxoids

Novel fluorine-containing taxoids with high potency against drug-resistant cancer. Background: Paclitaxel and docetaxel have been extensively used in clinic for treatment of various cancers. However, their lack of tumor-specificity frequently results in an assortment of undesired side effects and exhibit little efficacy in treating melanoma, pancreatic,...

Published: 8/29/2025 | Inventor(s): Iwao Ojima, Changwei Wang, Xin Wang

Keywords(s): Technologies

Category(s): Campus > Stony Brook University, Technology Classifications, Technology Classifications > Therapeutics and Vaccines

Biliverdin IXβ Reductase

Developing first-in-class therapy for patients with thrombocytopenia. Background: Thrombocytopenia is a medical condition characterized by low platelet counts. Thrombocytopenia can be brought on as a result of a separate disorder such as leukemia, an immune system problem or it can be an adverse result of taking medication, such as chemotherapy. Symptoms...

Published: 8/29/2025 | Inventor(s): Wadie Bahou, Song Wu

Keywords(s): Technologies

Category(s): Campus > Stony Brook University, Technology Classifications, Technology Classifications > Therapeutics and Vaccines

Benzimidazoles and Pharmaceutical Compositions Thereof

A novel cell division inhibitor with efficacy against Mycobacterium tuberculosis Background: Multidrug-resistant tuberculosis (MDR-TB) and extensively drug resistant TB (XDR-TB) are a significant public health threat for TB control efforts. Despite efforts in last 50 years, development of new TB treatments have been limited to drug targets like...

Published: 8/29/2025 | Inventor(s): Iwao Ojima, Seung-Yub Lee

Keywords(s): Technologies

Category(s): Campus > Stony Brook University, Technology Classifications, Technology Classifications > Therapeutics and Vaccines

Inhibition of the Soluble Extracellular Domain of E-cadherin: A Novel Tumoricidal Drug for Cancers

Monoclonal antibodies that have demonstrated profound antitumor effects both in vitro and in vivo. Background: Over the last decade, the most significant revolutionary advances in oncology have been the introduction and FDA approval of targeted monoclonal antibodies (mAb) against the human epidermal growth factor receptor (HER1-4) family. In combination...

Published: 8/29/2025 | Inventor(s): Sabine Brouxhon, Stephanos Kyrkanides, Marcia Simon, Li Ma, Liqun Wang, Soosan Ghazizadeh

Keywords(s): TAF, Technologies

Category(s): Campus > Stony Brook University, Technology Classifications, Technology Classifications > Therapeutics and Vaccines