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A Supramolecular Chitosan Complex Drug Delivery Platform

Using a supramolecular chitosan complex system to bind hydrophobic substances including small spherical molecules and/or linear chainsRSS.HDBackground> Background: <Since 1991, copolymers that form well-defined micelles in aqueous media have been studied and research has shown that these copolymers can trap water‑insoluble substances in their...

Published: 2/1/2024 | Inventor(s): Yizhi Meng

Keywords(s): Technologies

Category(s): Technology Classifications > Drug Delivery, Technology Classifications > Material and Composites, Campus > Stony Brook University

Immunostimulant-Cytotoxic Conjugates for Targeted Cancer Therapy

050-9150 Immunostimulant-Cytotoxic Conjugates for Targeted Cancer Therapy A unique immunotherapy paradigm to treat castrate-resistant prostate cancer and its metastatic form RSS.HDBackground> Background: < Prostate cancer is one of the leading causes of cancer death, with 1 in 10 men diagnosed in their lifetime and 1 in 41 dying from the...

Published: 8/24/2023 | Inventor(s): Labros Meimetis, Eszter Boros

Keywords(s): Technologies

Category(s): Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics, Campus > Stony Brook University

Novel Prodrugs for Selective Anticancer Therapy

Novel methods to make anticancer prodrugs by conjugating unique dual-substrate biochemical modules to known or novel chemotherapeutic drugs Background: Anticancer drug sales exceeded $50 billion worldwide in 2009 with impressive growth; however, lack of target selectivity is a major challenge in cancer treatment. The limitation of current chemotherapy...

Published: 11/22/2023 | Inventor(s): Michael Hayman, Nobuhide Ueki

Keywords(s): anticancer drugs, cancer-associated protease, HDAC, nucleoside analogues, Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Delivery, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Therapeutics

Porous Graphene Based Composite Membranes for Nanofiltration, Desalination and Pervaporation

An ultra-thin barrier from a single atomic layer of graphene-based materials with adjustable pore size Background: For membrane separation technology, preparing a very thin barrier layer with high selectivity, high throughput, low fouling, and long lasting properties forms the ultimate set of goals, which the widely used polymeric materials...

Published: 7/6/2023 | Inventor(s): Benjamin Chu, Benjamin Hsiao, Hongyang Ma, Zhe Wang

Keywords(s): chemically cross-linking, desalination, electrospun scaffold, membrane, nanofiltration, pervaporation, Porous graphene oxide, Technologies, water channels

Category(s): Campus > Stony Brook University, Technology Classifications > Education and Training, Technology Classifications > Drug Delivery, Technology Classifications > Medical Devices

Degradable Polymeric Materials via Large Ring Alternating Ring Opening Metathesis Polymerization (AROMP)

An effective way of designing a myriad of intelligent materials that are readily degradable and easily synthesized Background: Ring opening metathesis polymerization is a technique which enables the synthesis of materials of diverse architecture owing to its tolerance to a large range of functionalities. Traditionally, the scope of monomers used yields...

Published: 11/22/2023 | Inventor(s): Nicole Sampson, Jingling Zhang, Francis Boadi, Guofang Li

Keywords(s):

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Delivery, Technology Classifications > Electronics and Electronic Materials, Technology Classifications > Material and Composites, Technology Classifications > Therapeutics

Novel Bioabsorbable Membranes for Cell Delivery Applications

Methods for storing viable cells and for delivering viable cells to a mammal using the cell storage and delivery system. Background: Methods and compositions for encapsulating core materials, e.g., materials containing drugs, have been disclosed. These methods generally involve encapsulating the core material within a micro capsule by forming...

Published: 11/22/2023 | Inventor(s): Benjamin Chu, Benjamin Hsiao, Michael Hadjiargyrou, Dufei Fang, Xinhua Zong, KwangSok Kim

Keywords(s):

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Delivery, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Gene Therapy and Viral Vectors

Triazibe-Based Tripod Linker System for Drug Delivery and Diagnosis

This tumor-targeted drug delivery system uses biotin as a tumor targeting moiety and taxoid-camptothecin combination. Background: Combination therapy is the primary treatment option against cancer, because multiple agents in combination, synergistically improve efficacy and are less prone to resistance due to their distinct action mechanisms. Despite...

Published: 2/28/2024 | Inventor(s): Iwao Ojima, Jacob Vineberg, Tao Wang

Keywords(s): Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Drug Delivery, Technology Classifications > Diagnostics, Technology Classifications > Therapeutics

Asymmetric Bow-Tie Dendrimers as Versatile Platform for Drug Delivery and Diagnosis

Novel multifunctional asymmetric bow-tie dendrimers as a robust platform for drug delivery systems and diagnostic agents. Background: Dendrimers are nano-sized globular macromolecules that have been well studied as a drug delivery vehicles. Their convenient synthesis strategy, easy functionalization of the terminal end group and versatility in designing,...

Published: 2/28/2024 | Inventor(s): Iwao Ojima, Yu Han Gary Teng, Tao Wang

Keywords(s): Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Delivery, Technology Classifications > Therapeutics, Technology Classifications > Research Tools and Reagents