Search Results - technology+classifications+%3e+drug+design+and+synthesis

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Taxane anticancer agents, their pharmaceutical compositions and their use

050-9465 Taxane anticancer agents, their pharmaceutical compositions and their use New taxane anticancer compounds designed with carbamate substituents at the C-10 position with lower cytotoxicity and superior potency Background: Despite advances in chemotherapeutic interventions, cancer remains the second largest cause of death in the United States....

Published: 5/7/2026 | Updated: 5/7/2026 | Inventor(s): Iwao Ojima, Hersh Bendale, Kalani Jayanetti, Ananya Shibana Thennarasu

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Category(s): Technology Classifications > Drug Design and Synthesis, Campus > Stony Brook University

Sterylglucosidase Inhibitors as Antifungal Agents

050-9346 Sterylglucosidase Inhibitors as Antifungal Agents Novel antifungal compounds that function as substrate-mimicking inhibitors of sterylglucosidase for antifungal medication and therapeutics Background: Invasive fungal infections, such as life-threatening meningoencephalitis caused by Cryptococcus neoformans and severe pulmonary aspergillosis...

Published: 5/4/2026 | Updated: 2/19/2026 | Inventor(s): Iwao Ojima, Maurizio Del Poeta, Michael Airola, Nivea Pereira de Sa, SeungYoun Shin, Kalani Jayanetti, Dominick Rendina, Ananya Shibana Thennarasu

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Category(s): Technology Classifications > Drug Design and Synthesis, Campus > Stony Brook University, Campus

Macrocycle-Based Chelators for Room Temperature Chelation of Radioactive Isotopes

050-9235 Macrocycle-Based Chelators for Room Temperature Chelation of Radioactive Isotopes Ternary complexes that produce robust radiopharmaceuticals with a high radiochemical yield and specific activity for enhanced radiolabeling Background: The management of various cancers, particularly prostate cancer, increasingly relies on targeted radiotherapeutics...

Published: 5/4/2026 | Updated: 2/13/2026 | Inventor(s): Eszter Boros, Brett Vaughn, Jennifer Whetter

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Category(s): Technology Classifications > Drug Design and Synthesis, Technology Classifications > Medical Imaging, Campus > Stony Brook University

LpxC Inhibitors for Gram-Negative Infections

Treatment of multidrug-resistant bacterial infections with LpxC inhibitors for reduced drug resistance and improved safety profiles RSS.HDBackground> Background: < Infection by Gram‑negative bacteria such as Pseudomonas aeruginosa, β‑lactamase producing (ESBL) Enterobacteriaceae, and Acinetobacter baumannii is a major health problem, especially...

Published: 7/25/2025 | Updated: 3/7/2025 | Inventor(s): Peter Tonge, Fereidoon Daryaee, Sneha Basak

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Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis

Design and Synthesis of Novel Methotrexate Conjugated MicroRNA Mimic Modified with 5-Fluorouracil and/or Gemcitabine as a Platform Technology for Cancer Treatment

A platform for modifying miRNAs and using the modified miRNAs as novel cancer therapeutics. RSS.HDBackground> Background: < Resistance to chemotherapy can be a highly complex issue, with epigenetic alterations playing a key role in tumorigenesis and chemotherapy resistance. The failure to treat several advanced solid tumors can be often attributed...

Published: 5/14/2026 | Updated: 3/7/2025 | Inventor(s): Jingfang Ju, Iwao Ojima, John Yuen, Lei Chen

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Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis

Concerted, Selective Radiometallation and Photo-triggered Release of Ready-to-Inject Radiopharmaceuticals from the Solid Phase

Solid Phase Radiometallation Photorelease method for the preparation of injectable radiopharmaceuticals RSS.HDBackground> Background: < Radiopharmaceuticals are agents which enable non-invasive patient diagnosis and personalized therapeutic intervention strategies. Radionuclides used in nuclear medicine applications must be purified after nuclear...

Published: 2/4/2025 | Updated: 2/3/2025 | Inventor(s): Eszter Boros, Dariusz Śmiłowicz

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Category(s): Technology Classifications > Diagnostics, Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis

6-azasteroids with unique activity in mycobacteria

The compound functions as potentiators of several anti-tuberculosis drugs RSS.HDBackground> Background: < One third of the world’s population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. There are drugs to combat the bacteria by attacking the bacteria directly. The current recommended treatment...

Published: 5/14/2025 | Updated: 2/3/2025 | Inventor(s): Nicole Sampson, Joshua Werman, Tianao Yuan

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Category(s): Technology Classifications, Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis

Metal-mediated, Autolytic Amide Bond Cleavage for the Selective, Metal-Complexation Catalyzed, Controlled Release of Metallodrugs

Autolytic, metal complex-mediated amide bond cleavage for prodrug activation and synthesis of metallodrugs RSS.HDBackground> Background: < Clinically viable prodrugs release activated drug molecules at the site of interest, requiring close spatiotemporal control. Bond cleavage strategies for the release of the activated drug often incorporate...

Published: 7/28/2025 | Updated: 1/30/2025 | Inventor(s): Eszter Boros, Dariusz Śmiłowicz

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Category(s): Technology Classifications > Drug Delivery, Campus, Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis

Immunostimulant-Cytotoxic Conjugates for Targeted Cancer Therapy

050-9150 Immunostimulant-Cytotoxic Conjugates for Targeted Cancer Therapy A unique immunotherapy paradigm to treat castrate-resistant prostate cancer and its metastatic form RSS.HDBackground> Background: < Prostate cancer is one of the leading causes of cancer death, with 1 in 10 men diagnosed in their lifetime and 1 in 41 dying from the...

Published: 7/25/2025 | Updated: 8/9/2022 | Inventor(s): Labros Meimetis, Eszter Boros

Keywords(s): Technologies

Category(s): Technology Classifications > Drug Delivery, Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis

Enzymatic Capsulotomy for Shoulder Adhesive Capsulitis

A minimally invasive collagenase injection method for treating frozen shoulder that is cost-effective Background: Adhesive capsulitis of the shoulder, more commonly known as frozen shoulder, results in painful limitation of shoulder motion. It can arise idiopathically or after trauma. The current standard of care is a long course of painful physical...

Published: 7/25/2025 | Updated: 8/27/2020 | Inventor(s): Marie Badalamente, Edward Wang

Keywords(s): Collagenase Injection, Frozen shoulder, Nonoperative Therapy, Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and Synthesis

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