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Sterylglucosidase Inhibitors as Antifungal Agents
050-9346 Sterylglucosidase Inhibitors as Antifungal Agents Novel antifungal compounds that function as substrate-mimicking inhibitors of sterylglucosidase for antifungal medication and therapeutics Background: Invasive fungal infections, such as life-threatening meningoencephalitis caused by Cryptococcus neoformans and severe pulmonary aspergillosis...
Published: 2/19/2026
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Inventor(s):
Iwao Ojima
,
Maurizio Del Poeta
,
Michael Airola
,
Nivea Pereira de Sa
,
SeungYoun Shin
,
Kalani Jayanetti
,
Dominick Rendina
,
Ananya Shibana Thennarasu
Keywords(s):
Category(s):
Technology Classifications > Drug Design and Synthesis
,
Campus > Stony Brook University
,
Campus
Novel Compounds and Methods for Treating Invasive Fungal Infections
Compounds that decrease the synthesis of glucosylceramide, a sphingolipid that promotes fungal infection Background: With the increasing number of immunodeficient subjects and the increase of the lifespan of these subjects due to the advance in medicine, there has been a concomitant rise in the number of cases of life-threatening fungal infections....
Published: 8/29/2025
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Inventor(s):
Maurizio Del Poeta
,
Visesato Mor
Keywords(s):
antifungal
,
fungal infection
,
glucosylceramide
,
sphingolipid
,
Technologies
Category(s):
Campus > Stony Brook University
,
Technology Classifications > Therapeutics and Vaccines