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LpxC Inhibitors for Gram-Negative Infections

Treatment of multidrug-resistant bacterial infections with LpxC inhibitors for reduced drug resistance and improved safety profiles RSS.HDBackground> Background: < Infection by Gram‑negative bacteria such as Pseudomonas aeruginosa, β‑lactamase producing (ESBL) Enterobacteriaceae, and Acinetobacter baumannii is a major health problem, especially...

Published: 3/7/2025 | Inventor(s): Peter Tonge, Fereidoon Daryaee, Sneha Basak

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Category(s): Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Therapeutics, Campus > Stony Brook University

Design and Synthesis of Novel Methotrexate Conjugated MicroRNA Mimic Modified with 5-Fluorouracil and/or Gemcitabine as a Platform Technology for Cancer Treatment

A platform for modifying miRNAs and using the modified miRNAs as novel cancer therapeutics. RSS.HDBackground> Background: < Resistance to chemotherapy can be a highly complex issue, with epigenetic alterations playing a key role in tumorigenesis and chemotherapy resistance. The failure to treat several advanced solid tumors can be often attributed...

Published: 3/7/2025 | Inventor(s): Jingfang Ju, Iwao Ojima, John Yuen, Lei Chen

Keywords(s):

Category(s): Technology Classifications > Therapeutics, Technology Classifications > Drug Design and/or Synthesis, Campus > Stony Brook University

Handheld Terahertz Three-dimensional Spectral Scanner

A portable handheld spectral reflection (PHASR) scanner to characterize, diagnose burn injuries and predict wound healing outcomes RSS.HDBackground> Background: < Terahertz time-domain spectroscopy is a technique that has shown promise in biomedical imaging for the diagnosis of burn wounds. However, current portable terahertz imagers are either...

Published: 2/4/2025 | Inventor(s): Mohammad Arbab, Zachery Harris

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Category(s): Technology Classifications > Diagnostics, Technology Classifications > Medical Imaging, Technology Classifications > Optics and Photonics, Campus > Stony Brook University

Concerted, Selective Radiometallation and Photo-triggered Release of Ready-to-Inject Radiopharmaceuticals from the Solid Phase

Solid Phase Radiometallation Photorelease method for the preparation of injectable radiopharmaceuticals RSS.HDBackground> Background: < Radiopharmaceuticals are agents which enable non-invasive patient diagnosis and personalized therapeutic intervention strategies. Radionuclides used in nuclear medicine applications must be purified after nuclear...

Published: 2/4/2025 | Inventor(s): Eszter Boros, Dariusz Śmiłowicz

Keywords(s):

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Drug Design and/or Synthesis, Campus > Stony Brook University

An anti-capsular antibody that cross protects against clade 1 Carbapenem-resistant Klebsiella pneumoniae

A monoclonal antibody that exhibits cross-protective efficacy against multiple ST258 CR-Kp strains RSS.HDBackground> Background: < Therapeutic monoclonal antibodies (mAbs) have emerged as a dominant therapeutic modality to treat cancer, immune disorders, and infectious diseases such as high-mortality Carbapenem-resistant Klebsiella pneumoniae...

Published: 2/4/2025 | Inventor(s): Kasturi Banerjee, Bettina Fries, Michael Motley

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Category(s): Technology Classifications > Therapeutics, Technology Classifications > Antibodies, Campus > Stony Brook University

6-azasteroids with unique activity in mycobacteria

The compound functions as potentiators of several anti-tuberculosis drugs RSS.HDBackground> Background: < One third of the world’s population is infected with tuberculosis (TB). In 2014, there were 1.5 million TB related deaths. There are drugs to combat the bacteria by attacking the bacteria directly. The current recommended treatment...

Published: 2/4/2025 | Inventor(s): Nicole Sampson, Joshua Werman, Tianao Yuan

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Category(s): Technology Classifications, Technology Classifications > Drug Design and/or Synthesis, Campus > Stony Brook University

A Closed-Loop Stimulation Controller for Exploring Neural States

A brand-new type of reinforcement learning algorithm RSS.HDBackground> Background: < Current day algorithms governing how medical devices deliver stimulation to patients have not changed in well over 50 years and cannot account for neurological variabilities across individuals that come about from differences in genetics, lifestyle factors,...

Published: 2/4/2025 | Inventor(s): Ian Jordan, Il Park, Josue Nassar

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Category(s): Technology Classifications > Artificial Intelligence, Technology Classifications > Computer Software, Technology Classifications > Therapeutics, Technology Classifications > Medical Devices, Campus, Campus > Stony Brook University

Novel Steel Composite for Nuclear Shielding

Structural steel composite for shielding against neutrons and electromagnetic radiation RSS.HDBackground> Background: < In nuclear reactor environments, particularly within fission and fusion reactor cores, effective radiation shielding is critical to ensure both the safety and longevity of the structural components. These reactor cores are...

Published: 1/30/2025 | Inventor(s): Lance Snead, David Sprouster

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Category(s): Technology Classifications > Material and Composites, Campus > Stony Brook University

Metal-mediated, Autolytic Amide Bond Cleavage for the Selective, Metal-Complexation Catalyzed, Controlled Release of Metallodrugs

Autolytic, metal complex-mediated amide bond cleavage for prodrug activation and synthesis of metallodrugs RSS.HDBackground> Background: < Clinically viable prodrugs release activated drug molecules at the site of interest, requiring close spatiotemporal control. Bond cleavage strategies for the release of the activated drug often incorporate...

Published: 2/4/2025 | Inventor(s): Eszter Boros, Dariusz Śmiłowicz

Keywords(s):

Category(s): Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Drug Delivery, Campus, Campus > Stony Brook University

Reactive Phase Sintering of Oxide Dispersion Strengthened Nanocrystalline Alloys

A low-temperature method of creating aluminum-magnesium alloys RSS.HDBackground> Background: < Aluminum is ubiquitous in many aspects of our life, from cans, to personal electronics, and to frames in automobiles. Though for many of these products, the aluminum should be as strong as possible. Dispersoids are important for increasing the strength...

Published: 1/29/2025 | Inventor(s): Jason Trelewicz, Bin Cheng, David Sprouster

Keywords(s):

Category(s): Technology Classifications > Material and Composites, Campus > Stony Brook University

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