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Development of a Pediatric Tuberculosis Diagnostic Test
A lipoprotein diagnostic marker for TB disease ideal for a simple diagnostic assay from a finger prick blood or serum Background: The inadequate sensitivity of available organism-based TB diagnostic tools in children, the wide spectrum of disease observed in children, and the non-specific signs and symptoms especially in young and HIV-children,...
Published: 2/28/2024
|
Inventor(s):
Nicole Sampson
,
Xinxin Yang
Keywords(s):
antibody
,
biomarker
,
diagnosis
,
ELISA
,
modified LDL
,
Technologies
,
tuberculosis
Category(s):
Campus > Stony Brook University
,
Technology Classifications > Antibodies
,
Technology Classifications > Diagnostics
Methods of Treating and Preventing Angioedema and Vascular Leakage
Peptides and antibodies that block vascular permeability induced in angioedema patients that are new targets for treatment. Background: Angioedema associated with C1-INH deficiency is an inherited or acquired condition that affects 20 per cent of the population. The condition can be disfiguring, painful and sometimes fatal. Existing treatments primarily...
Published: 11/22/2023
|
Inventor(s):
Berhane Ghebrehiwet
Keywords(s):
angioedema
,
gClqR
,
Medical
,
Monoclonal antibody
,
peptides
,
Technologies
,
vascular leakage
Category(s):
Campus > Stony Brook University
,
Technology Classifications > Antibodies
,
Technology Classifications > Therapeutics
Monoclonal Antibody, Anti Ft LVS LpnA/Tu14 Clone 164
An intracellular bacterium that can initiate the human response to Tularemia Background: Francisella tularensis is an intracellular, gram-negative bacterium that invades macrophages and initiates the human immune response. Technology Overview: Tularemia, commonly known as ?rabbit fever? can be communicated across several species including;...
Published: 2/28/2024
|
Inventor(s):
Jorge Benach
,
Anne Savitt
Keywords(s):
Anti Ft LVS LpnA/Tul4 Clone 164
,
Biological or Antibody
,
Monoclonal antibody
,
Technologies
Category(s):
Campus > Stony Brook University
,
Technology Classifications > Antibodies
,
Technology Classifications > Research Tools and Reagents
Novel Monoclonal Antibodies to Treat Carbapenem-Resistant Klebsiella Pneumoniae Infections
These mABs elicit phagocytic activity and protective immune response to clear bacteria from infected mice. Background: Carbapenem-resistant K.pneumonia (CR-Kp) strains are a major threat worldwide due to the difficult to treat. Lack of new antibiotics in pipeline and the emergence of resistance to the last-resource antibiotics has resulted in an urgent...
Published: 11/22/2023
|
Inventor(s):
Bettina Fries
,
Elizabet Diago Navarro
Keywords(s):
Technologies
Category(s):
Campus > Stony Brook University
,
Technology Classifications > Antibodies
,
Technology Classifications > Diagnostics
,
Technology Classifications > Therapeutics
Single Chain Antibody (Mab69) Against the NG2 Proteoglycan
AAV based viral vectors that express either AAV-NG2Ab or AAV-NT3 have been shown to provide improved recovery of motor function in models. Background: Spinal Cord Injury (SCI) affects nearly 270,000 Americans and is a common cause of permanent disability and death in children and adults. Despite being a significant burden to the patients, society...
Published: 2/28/2024
|
Inventor(s):
Joel Levine
,
Victor Arvanian
Keywords(s):
Technologies
Category(s):
Campus > Stony Brook University
,
Technology Classifications > Antibodies
,
Technology Classifications > Gene Therapy and Viral Vectors
,
Technology Classifications > Therapeutics