Search Results - jian+cao

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Novel Inhibitors of Matrix Metalloproteinase-9 for Anti-Cancer Drug Development

Inhibitors that target a site on MMP-9's hemopexin domain that are distinct and cannot be functionally substituted for one another. Background: Matrix Metalloproteinase-9 (MMP-9), a type IV collagenase, is linked to cancer progression and metastasis. Despite increased evidence of correlation between MMP-9 and tumor metastasis, no success has been...

Published: 9/27/2024 | Inventor(s): Vincent Alford, Anushree Kamath, Jian Cao, Nicole Sampson, Iwao Ojima, Xiaodong Ren, Monaf Awwa

Keywords(s): Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Drug Design and/or Synthesis, Technology Classifications > Research Tools and Reagents

High-Throughput 3-D Invasion Assay

A novel invasion plate design and methods which enables increased throughput, standardization and quantification of cell invasion. Background: The ability of cancer cells to invade into surrounding matrices is a critical determinant of metastasis and failure to prevent metastasis has reinforced the unmet need of targeting cancer invasion. To expedite...

Published: 8/27/2024 | Inventor(s): Jian Cao, Yizhi Meng, Vincent Alford

Keywords(s): Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Screens and Assays, Technology Classifications > Therapeutics, Technology Classifications > Research Tools and Reagents