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An anti-capsular antibody that cross protects against clade 1 Carbapenem-resistant Klebsiella pneumoniae

A monoclonal antibody that exhibits cross-protective efficacy against multiple ST258 CR-Kp strains RSS.HDBackground> Background: < Therapeutic monoclonal antibodies (mAbs) have emerged as a dominant therapeutic modality to treat cancer, immune disorders, and infectious diseases such as high-mortality Carbapenem-resistant Klebsiella pneumoniae...

Published: 2/4/2025 | Inventor(s): Kasturi Banerjee, Bettina Fries, Michael Motley

Keywords(s):

Category(s): Technology Classifications > Therapeutics, Technology Classifications > Antibodies, Campus > Stony Brook University

Methods of Treating and Preventing Angioedema and Vascular Leakage

Peptides and antibodies that block vascular permeability induced in angioedema patients that are new targets for treatment. Background: Angioedema associated with C1-INH deficiency is an inherited or acquired condition that affects 20 per cent of the population. The condition can be disfiguring, painful and sometimes fatal. Existing treatments primarily...

Published: 10/3/2024 | Inventor(s): Berhane Ghebrehiwet

Keywords(s): angioedema, gClqR, Medical, Monoclonal antibody, peptides, Technologies, vascular leakage

Category(s): Campus > Stony Brook University, Technology Classifications > Antibodies, Technology Classifications > Therapeutics

Monoclonal Antibody, Anti Ft LVS LpnA/Tu14 Clone 164

An intracellular bacterium that can initiate the human response to Tularemia Background: Francisella tularensis is an intracellular, gram-negative bacterium that invades macrophages and initiates the human immune response. Technology Overview: Tularemia, commonly known as ?rabbit fever? can be communicated across several species including;...

Published: 10/3/2024 | Inventor(s): Jorge Benach, Anne Savitt

Keywords(s): Anti Ft LVS LpnA/Tul4 Clone 164, Biological or Antibody, Monoclonal antibody, Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Antibodies, Technology Classifications > Research Tools and Reagents

Novel Monoclonal Antibodies to Treat Carbapenem-Resistant Klebsiella Pneumoniae Infections

These mABs elicit phagocytic activity and protective immune response to clear bacteria from infected mice. Background: Carbapenem-resistant K.pneumonia (CR-Kp) strains are a major threat worldwide due to the difficult to treat. Lack of new antibiotics in pipeline and the emergence of resistance to the last-resource antibiotics has resulted in an urgent...

Published: 11/22/2023 | Inventor(s): Bettina Fries, Elizabet Diago Navarro

Keywords(s): Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Antibodies, Technology Classifications > Diagnostics, Technology Classifications > Therapeutics

Single Chain Antibody (Mab69) Against the NG2 Proteoglycan

AAV based viral vectors that express either AAV-NG2Ab or AAV-NT3 have been shown to provide improved recovery of motor function in models. Background: Spinal Cord Injury (SCI) affects nearly 270,000 Americans and is a common cause of permanent disability and death in children and adults. Despite being a significant burden to the patients, society...

Published: 9/4/2024 | Inventor(s): Joel Levine, Victor Arvanian

Keywords(s): Technologies

Category(s): Campus > Stony Brook University, Technology Classifications > Antibodies, Technology Classifications > Gene Therapy and Viral Vectors, Technology Classifications > Therapeutics