Methods of Treating and Preventing Angioedema and Vascular Leakage

Background

Angioedema associated with C1-INH deficiency is an inherited or acquired condition that affects 20 per cent of the population. The condition can be disfiguring, painful and sometimes fatal. Existing treatments primarily replace or enhance the production of C1-INH, but these options are limited to availability, price, side effects, and long term risks. New therapeutic modalities that address these issues are sorely needed.

Technology

Researchers at Stony Brook University have identified proprietary peptides and antibodies that are being used in a novel mechanism of action to block the vascular permeability that is induced by the attack phase of plasma in the C1-INH deficient AE patients. This mechanism of action relates to blocking bradykinin (BK) production and the complement activation, key mediators of episodic AE.

Advantages

New target and compositions for the treatment of AE - Novel mechanism of action for blocking the production of BK and the complement activation

Application

Diagnostic and therapeutic applications for hereditary and drug-induced AE.

Patent Status

Patented

Stage Of Development

In vitro data is available. Issued patent # 8,883,153

Licensing Potential

Development partner - Commercial partner - Licensing

Licensing Status

Available for license. The team seeks to develop and commercialize, by an exclusive or non-exclusive license agreement and/or sponsored research, with a company active in the area.

Additional Info

Additional Information:

https://stonybrook.technologypublisher.com/files/sites/8114----methods-of-treating-and-preventing-angioedema-and-vascular-leakage.jpg Please note, header image is purely illustrative. Source: ustas, stock.adobe.com/uk/212148709, stock.adobe.com