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High-Throughput 3-D Invasion Assay
Case ID:
8831
Web Published:
1/24/2020
Background
The ability of cancer cells to invade into surrounding matrices is a critical determinant of metastasis and failure to prevent metastasis has reinforced the unmet need of targeting cancer invasion. To expedite the overall drug screening process, considerable efforts have been focused on development of practical 3D cell culture platforms for drug discovery. However, current 3D cell-based assays have not yet been incorporated into drug development programs that target metastatic process due to long incubation time requirement, lack standardization, or do not permit standardization for high- throughput screening.
Technology
Stony Brook University researchers have developed fluorine-containing asion in addition to being a inducer of apoptonext‐generation taxoid anticancer agents with superior pharmacological properties and improved potency against various classes of tumors, in particular drug‐resistant cancers and cancer stem cells. The potency of these next‐generation taxoids was evaluated against various drug‐sensitive and drug‐resistant cancer cell lines and patient‐derived cancer stem cells. The lead compound is a potent inhibitor of epithelial-mesenchymal transition(EMT), migration and invasion in breast cancer cells. Highly potent taxoids are also very important as the warheads of tumor‐targeting drug conjugates. Further Details Zheng et al. Int J Oncolocy 2017 Mar; 50(3): 893-902
Advantages
- Permits standardized high throughput drug screening - Effective and reproducible - Can be used with multiple cell types- Enables automated screening
Application
- Research - Drug Discovery
Patent Status
Patented,Patent application submitted
Stage Of Development
Issued Patent: 8,900,851 Pending Application
Licensing Potential
Licensing Status
Additional Info
https://stonybrook.technologypublisher.com/files/sites/qf8o70atsjos00fxvmbe_6_wells_cell_culture_plate-03.jpg
Please note, header image is purely illustrative. Source: Lily_M, Wikimedia Commons, CC BY-SA 3.0.
Patent Information:
App Type
Country
Serial No.
Patent No.
File Date
Issued Date
Expire Date
Category(s):
Campus > Stony Brook University
Technology Classifications > Screens and Assays
Technology Classifications > Therapeutics
Technology Classifications > Research Tools and Reagents
Case ID: R8831
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For Information, Contact:
Sean Boykevisch
Director
State University of New York at Stony Brook
6316326952
sean.boykevisch@stonybrook.edu
Inventors:
Jian Cao
Yizhi Meng
Vincent Alford
Keywords:
Technologies