Triazamacrocycle-derived chelators for the coordination of imaging and therapy metal ions

Background

Personalized medicine, or individually tailored patient treatment, is an emerging clinical management paradigm. In nuclear medicine, this entails exploiting diagnostic techniques, such as non-invasive imaging by means of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT), to modify radiotherapeutic treatment regimes. If the same drug is labeled with a diagnostic and a therapeutic radionuclide for sequential imaging and treatment, the approach is considered “theranostic.” Theranostic isotope pairs enable diagnostic imaging that is directly, accurately and reliably predictive of therapy and imaging can be carried out for prolonged periods of time. However, in order to utilize metallic theranostic isotope pairs, customized chelation approaches are required that enable targeted delivery of isotope payload to the site of interest.

Technology

⁴⁴Scandium and ⁶⁴copper have recently emerged as an attractive, short-lived, PET isotopes with a matched radiotherapeutic isotope for radio therapy (⁴⁷Sc, ⁶⁷Cu, ¹⁷⁷Lu). In this invention, novel, modular chemical entities with high affinity to copper, scandium and lutetium radioisotopes and a freely functionalizable moiety have been synthesized. These constructs are suitable to kit-type formulations for single-step radiochemical synthesis of diagnostic and therapeutic entities radiolabeled with scandium, copper and lutetium isotopes, and are readily suitable for applications using other any desirable targeting vectors of peptidic/small molecule, protein or antibody nature.

Advantages

This technology allows for rapid and inert radiolabeling with an array of radioactive isotopes suitable for imaging and therapy approaches. This renders the technology superior to currently commercially available ¹⁸F-, ⁶⁸G-, and ¹⁷⁷Lu-based tracers.

Application

Cancer diagnostics and therapeutics.

Patent Status

PCT/US2019/038318; PCT 2021-0276971-A!

Stage Of Development

Preclinical, animal data available.

Licensing Potential

Development partner - Commercial partner - Licensing

Licensing Status

Available for licensing

Additional Info

Additional Information:

https://stonybrook.technologypublisher.com/files/sites/9011-triazamacrocycle-derived-chelators-for-the-coordination-of-imaging-and-therapy-metal-ions.jpeg1.jpg

Category(s):

Medical Imaging

Campus > Stony Brook University

Case ID: R050-9011

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For Information, Contact:

Valery Matthys

Licensing Associate

State University of New York at Stony Brook

valery.matthys@stonybrook.edu

Inventors:

Eszter Boros

Brett Vaughn

Keywords:

Technologies