Novel 18F-Labeled PET-Tracers for Use in Treatment of Neurological Disorders


Dysregulation of Glycogen Synthase Kinase 3β (GSK3β) is associated with several neurodegenerative diseases, such as Parkinson’s, Alzheimer’s and Huntington’s. Therefore, development of a selective GSK3β PET tracer would enable both, early detection of its aberrant activity and facilitate therapeutic drug discovery. However, efforts to develop a potent tracer has remained unsuccessful due to either poor penetration of the blood-brain-barrier (BBB) and/ or short half life of traditional radio-label conjugate, 11C, used as a radio-label.


Researchers at Stony Brook University have developed novel 18F radiolabeled GSK3β inhibitors. 18F radiolabeling offer several advantages to these inhibitors:-Long half life (t1/2 = 109.7m) which eliminates the reliance on in-house cyclotron thus facilitating wide spread use.-Better spatial resolution and image quality due to short range positron emission. Additionally, these compounds are highly potent (IC50 = 1.7nM) and have been demonstrated to cross BBB in rodents (Figure 1.).Further Details: Hu et al. ACS Medicinal Chemistry Letters, 8, 287-292, 2017


Longer t1/2 of 18F ( vs traditional 11C) labeled tracers-Demonstrated brain penetration-Improved spatial resolution and image quality-High potency


- Medical Imaging- Diagnostics- Therapeutics 

Patent Status

Patent application submitted

Stage Of Development

PCT application covering compositions and methods of use (PCT/US18/13446).

Licensing Potential


Licensing Status


Additional Info Please note, header image is purely illustrative. Source: SciBiograph, Wikimedia Commons, CC BY-SA 4.0, edited.
Patent Information:
Case ID: R050-8894
For Information, Contact:
Valery Matthys
Licensing Associate
State University of New York at Stony Brook
Ming-Yu Ngai
Katarzyna Lee
Kongzhen Hu *credit to use
Neil Nasdev
Stephen Haggarty