Intralipid as a Contrast Agent to Enhance Subsurface Blood Flow Imaging


Conventional techniques (for example, MRI and CT angiography) fail to provide sufficient spatiotemporal resolutions to measure rapid cerebral blood flow changes in small vessels which restricts its use for assessing cerebrovascular networks, and may not be suitable for repeated imaging of disease progression.


Dr. Yingtian Pan, Professor at Stony Brook University created a novel 3D neuro-imaging technique to investigate functional changes in the small neurovascular network that may be implicated by stroke and other neurovascular diseases. Technique validated in mouse brain to study the cerebral micro vascular network changes induced by acute cocaine administration using clinically relevant doses. NDA to be executed with Vuetek Scientific.


Detect minute microcirculation, which is critical to early detection of neo-angiogenesis after wound healing, detection of tumor micro-environment, retinal blood flow imaging, functional brain imaging, and neuronal rehabilitation


Neurovascular disease imaging

Patent Status

PCT Publication No. WO 2014-012042

Stage Of Development

Prototype is available for demonstration.

Licensing Potential

We seek to develop and commercialize, by an exclusive or non-exclusive license agreement and/or sponsored research, with a company active in the area.

Licensing Status

Available for License

Additional Info  
Patent Information:
Case ID: R8444
For Information, Contact:
Valery Matthys
Licensing Associate
State University of New York at Stony Brook
Yingtian Pan
Congwu Du
Hugang Ren