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Stabilized Coronavirus Spike Glycoproteins in the Pre-Fusion Conformation

Pre-fusion stabilized SARS CoV-2 spike glycoproteins by the introduction of a "stapling" disulfide bondRSS.HDBackground> Background: <Coronavirus uses the spike (S) protein to gain entry into host cells. The S protein binds to host cell receptors, leading to a series of conformational changes that convert the pre-fusion S structure into...

Published: 5/19/2023 | Inventor(s): Carlos Simmerling

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Category(s): Technology Classifications > COVID, Technology Classifications > Protein/Peptide, Campus > Stony Brook University