Decellularized Engineered Vascularized Skin Architecture (DEVA)

Background

Chronic skin wounds, burns, and surgical defects account for millions of medical cases annually, and lead to significant morbidity. Existing advanced wound care solutions often fall short due to poor graft integration, delayed vascularization, immune rejection, and limited shelf stability, leading to longer recovery times. There is a critical unmet need for off‑the‑shelf, vascularized, acellular skin substitutes to address these shortcomings while being scalable for widespread clinical use.

Technology

Decellularized Engineered Vascularized Skin Architecture (DEVA) is a shelf‑stable, vascularized, acellular skin substitute that can be applied for treatment of complex wounds, burns, and surgical defects. It is designed as an off‑the‑shelf biologic that facilitates rapid revascularization, using extracellular matrix and vascular structures, and graft integration without the need for cellular seeding. By creating pre-vascularized, biocompatible skin substitutes through cutting-edge 3D bioprinting and specialized decellularization techniques, DEVA will accelerate healing, reduce scarring, and enhance patient outcomes. The technology is versatile and can be applied in various healthcare settings, including hospitals, burn centers, and outpatient clinics, as well as in emergency and military medical scenarios. DEVA has the potential to significantly improve the quality of life for patients with challenging wounds and reduce overall healthcare costs by promoting faster recovery and minimizing complications.

Advantages

Enhanced Vascularization - Reduced Immune Rejection - Minimized Scarring - Patient Specific Customization - Faster Heal Times - Lower Risk of Graft Failure or Infection - Scalable - Environmentally Friendly Decellularization

Application

Skin Graft Procedures - Burn Treatment - Wound Healing Kits - Diabetic Ulcer Treatment - Cosmetic Reconstruction - Veterinary Skin Grafts - Regenerative Medicine Research - Chronic Wound Management - Military and Aerospace Medical Solutions